Chronic and refractory pain: A systematic review of pharmacologic management in oncology Journal Article


Authors: Brant, J. M.; Keller, L.; McLeod, K.; Yeh, C.; Eaton, L. H.
Article Title: Chronic and refractory pain: A systematic review of pharmacologic management in oncology
Abstract: BACKGROUND: Chronic and refractory cancer pain are significant issues and can increase patient suffering and compromise quality of life. A variety of evidence-based pharmacologic strategies can be used routinely to control cancer pain. OBJECTIVES: The purpose of this study is to conduct a systematic review of the pharmacologic evidence in the management of chronic and refractory cancer pain. METHODS: The Oncology Nursing Society’s Putting Evidence Into Practice pain team conducted a search of 184 systematic reviews, meta-analyses, research studies, and guidelines and classified the evidence into weight-of-evidence categories. FINDINGS: Opioids are the mainstay of cancer pain management, but evidence supports the use of coanalgesics and adjuvants to improve overall pain management. Complementary pharmacologic strategies, such as caffeine and herbal preparations, are under investigation, but additional research is needed to recommend these modalities. © 2017 by the Oncology Nursing Society.
Keywords: chronic pain; opioids; adjuvants; coanalgesics; refractory pain
Journal Title: Clinical Journal of Oncology Nursing
Volume: 21
Issue: 3 Suppl.
ISSN: 1092-1095
Publisher: Oncology Nursing Society (ONS)  
Date Published: 2017-06-01
Start Page: 31
End Page: 53
Language: English
DOI: 10.1188/17.cjon.s3.31-53
PROVIDER: scopus
PUBMED: 28524906
DOI/URL:
Notes: Review -- Export Date: 2 August 2017 -- Source: Scopus
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  1. Lisa A Keller
    2 Keller