Noninvasive interrogation of DLL3 expression in metastatic small cell lung cancer Journal Article
| Authors: | Sharma, S. K.; Pourat, J.; Abdel-Atti, D.; Carlin, S. D.; Piersigilli, A.; Bankovich, A. J.; Gardner, E. E.; Hamdy, O.; Isse, K.; Bheddah, S.; Sandoval, J.; Cunanan, K. M.; Johansen, E. B.; Allaj, V.; Sisodiya, V.; Liu, D.; Zeglis, B. M.; Rudin, C. M.; Dylla, S. J.; Poirier, J. T.; Lewis, J. S. |
| Article Title: | Noninvasive interrogation of DLL3 expression in metastatic small cell lung cancer |
| Abstract: | The Notch ligand DLL3 has emerged as a novel therapeutic patients for treatment with Rova-T based on a noninvasive inter-target expressed in small cell lung cancer (SCLC) and high-grade rogation of the in vivo status of DLL3 expression using PET imaging. neuroendocrine carcinomas. Rovalpituzumab teserine (Rova-T; Despite low cell-surface abundance of DLL3, immunoPET imaging SC16LD6.5) is a first-in-class DLL3-targeted antibody–drug con-with 89Zr-labeled SC16 antibody enabled delineation of subcu-jugate with encouraging initial safety and efficacy profiles in SCLC taneous and orthotopic SCLC tumor xenografts as well as distant in the clinic. Here we demonstrate that tumor expression of DLL3, organ metastases with high sensitivity. Uptake of the radiotracer in although orders of magnitude lower in surface protein expression tumors was concordant with levels of DLL3 expression and, most than typical oncology targets of immunoPET, can serve as an notably, DLL3 immunoPET yielded rank-order correlation for imaging biomarker for SCLC. We developed 89Zr-labeled SC16 response to SC16LD6.5 therapy in SCLC patient–derived xeno-antibody as a companion diagnostic agent to facilitate selection of graft models. 2017 American Association for Cancer Research. |
| Journal Title: | Cancer Research |
| Volume: | 77 |
| Issue: | 14 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2017-07-01 |
| Start Page: | 3931 |
| End Page: | 3941 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-17-0299 |
| PROVIDER: | scopus |
| PMCID: | PMC5534176 |
| PUBMED: | 28487384 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2017 -- Source: Scopus |
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