The precision of hepatic arterial infusion scintigraphy as a quantitative biomarker of tumor microvasculature Journal Article
| Authors: | Dunphy, M.; Pandit-Taskar, N.; Fox, J. J.; Kemeny, N. |
| Article Title: | The precision of hepatic arterial infusion scintigraphy as a quantitative biomarker of tumor microvasculature |
| Abstract: | OBJECTIVE. Optimal clinical development of new cancer therapies targeting tumor vasculature requires new target-specific response assays. This clinical study examined the testretest repeatability of SPECT as an in vivo assay of angiogenic hepatic tumor microvasculature using an intraarterial infusion of 99mTc-macroaggregated albumin (MAA) delivered via a hepatic artery infusion (HAI) pump. MATERIALS AND METHODS. Patients with primary or secondary cancerous liver tumors with HAI pump-catheter implants placed for HAI chemotherapy underwent hepatic SPECT after separate arterial infusions of 37 and 185 MBq of 99mTc-MAA via an HAI pump. Quantitative measures of hepatic tumor MAA uptake were obtained from paired test-retest SPECT datasets. Repeatability was defined by quotients of paired measurands with 95% CIs and coefficients of repeatability (CRs). RESULTS. Test-retest HAI pump SPECT yielded highly repeatable measurements in quantitative indexes of tumor microvasculature. Variability in repeat test-retest measurements was small relative to the range of observed measurements between different tumors. The total hepatic tumor microvascular MAA accumulation (percentage injected dose) proved most repeatable, with test-retest value quotients near unity (quotients: median, 1.10 ± 0.09 [SD]; range, 1.03-1.32; 95% CI, 1.07-1.19) and 1.6% CR. Tumor MAA uptake values ranged from 5% to 18% injected dose. CONCLUSION. This article describes the precision of HAI SPECT as a quantitative biomarker of tumor microvasculature under conditions of repeatability. The results support clinical testing of HAI SPECT as a radiologic response biomarker for angiotropic tumor therapy. © American Roentgen Ray Society. |
| Keywords: | liver neoplasms; angiogenesis inhibitors; neovascularization; yttrium radioisotopes; microspheres; pathologic neovascularization |
| Journal Title: | American Journal of Roentgenology |
| Volume: | 209 |
| Issue: | 1 |
| ISSN: | 0361-803X |
| Publisher: | American Roentgen Ray Society |
| Date Published: | 2017-07-01 |
| Start Page: | 182 |
| End Page: | 186 |
| Language: | English |
| DOI: | 10.2214/ajr.16.17560 |
| PROVIDER: | scopus |
| PUBMED: | 28537788 |
| PMCID: | PMC5577942 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2017 -- Source: Scopus |
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342Pandit-Taskar -
543Kemeny
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