GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer Journal Article

   

Authors:	Chen, M. M.; O'Mara, T. A.; Thompson, D. J.; Painter, J. N.; Australian National Endometrial Cancer Study Group (ANECS); Attia, J.; Black, A.; Brinton, L.; Chanock, S.; Chen, C.; Cheng, T. H. T.; Cook, L. S.; Crous-Bou, M.; Doherty, J.; Friedenreich, C. M.; Garcia-Closas, M.; Gaudet, M. M.; Gorman, M.; Haiman, C.; Hankinson, S. E.; Hartge, P.; Henderson, B. E.; Hodgson, S.; Holliday, E. G.; Horn-Ross, P. L.; Hunter, D. J.; Le Marchand, L.; Liang, X. L.; Lissowska, J.; Long, J. R.; Lu, L. G.; Magliocco, A. M.; Martin, L.; McEvoy, M.; National Study Of Endometrial Cancer Genetics Group (NSECG); Olson, S. H.; Orlow, I.; Pooler, L.; Prescott, J.; Rastogi, R.; Rebbeck, T. R.; Risch, H.; Sacerdote, C.; Schumacher, F.; Wendy Setiawan, V. W.; Scott, R. J.; Sheng, X.; Shu, X. O.; Turman, C.; Van Den Berg, D.; Wang, Z. M.; Weiss, N. S.; Wentzensen, N.; Xia, L.; Xiang, Y. B.; Yang, H. P.; Yu, H.; Zheng, W.; Pharoah, P. D. P.; Dunning, A. M.; Tomlinson, I.; Easton, D. F.; Kraft, P.; Spurdle, A. B.; De Vivo, I.
Article Title:	GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer
Abstract:	Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Keywords:	single nucleotide polymorphism; genetics; polymorphism, single nucleotide; endometrial neoplasms; genetic predisposition to disease; genotype; genome-wide association study; pathology; chromosomes, human, pair 6; genetic predisposition; european continental ancestry group; endometrium tumor; chromosome 6; meta analysis; caucasian; humans; human; female
Journal Title:	Human Molecular Genetics
Volume:	25
Issue:	12
ISSN:	0964-6906
Publisher:	Oxford University Press
Date Published:	2016-06-15
Start Page:	2612
End Page:	2620
Language:	English
PUBMED:	27008869
PROVIDER:	scopus
DOI:	10.1093/hmg/ddw092
PMCID:	PMC5868213
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024098018&partnerID=40&md5=72fec46256a20501c101c49d5087b612
Notes:	Article -- Export Date: 2 August 2017 -- Source: Scopus

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