Cell of origin and cancer stem cells in tumor suppressor mouse models of glioblastoma Conference Paper
| Authors: | Alcantara Llaguno, S. R.; Xie, X.; Parada, L. F. |
| Title: | Cell of origin and cancer stem cells in tumor suppressor mouse models of glioblastoma |
| Conference Title: | 81st Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Targeting Cancer |
| Abstract: | The cellular origins and the mechanisms of progression, maintenance of tumorigenicity, and therapeutic resistance are central questions in the glioblastoma multiforme (GBM) field. Using tumor suppressor mouse models, our group recently reported two independent populations of adult GBM-initiating central nervous system progenitors. We found different functional and molecular subtypes depending on the tumor-initiating cell lineage, indicating that the cell of origin is a driver of GBMsubtype diversity. Using an in vivo model, we also showed that GBM cancer stem cells (CSCs) or glioma stem cells (GSCs) contribute to resistance to chemotherapeutic agents and that genetic ablation of GSCs leads to a delay in tumor progression. These studies are consistent with the cell of origin and CSCs as critical regulators of the pathogenesis of GBM. © 2016 Alcantara Llaguno et al. |
| Journal Title | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 81 |
| Conference Dates: | 2016 Jun 1-5 |
| Conference Location: | Cold Spring Harbor, NY |
| ISBN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2016-01-01 |
| Start Page: | 31 |
| End Page: | 36 |
| Language: | English |
| DOI: | 10.1101/sqb.2016.81.030973 |
| PROVIDER: | scopus |
| PUBMED: | 27815542 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2017 -- Source: Scopus |
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