Paraprotein-related kidney disease: Diagnosing and treating monoclonal gammopathy of renal significance Journal Article


Authors: Rosner, M. H.; Edeani, A.; Yanagita, M.; Glezerman, I. G.; Leung, N.; for the American Society of Nephrology Onco-Nephrology Forum
Article Title: Paraprotein-related kidney disease: Diagnosing and treating monoclonal gammopathy of renal significance
Abstract: Paraprotein-related kidney disease represents a complex group of diseases caused by an abnormal paraprotein secreted by a clone of B cells. The diseasemanifestations range from tubulopathies, such as the Fanconi syndrome, to a spectrum of glomerular diseases that can present with varying degrees of proteinuria and renal dysfunction. Diagnosis of these diseases can be challenging because of the wide range ofmanifestations as well as the relatively common finding of a serum paraprotein, especially in elderly patients. Thus, renal biopsy along with detailed hematologic workup is essential to link the presence of the paraprotein to the associated renal disease. Recent advances in treatment withmore effective and targeted chemotherapies, as well as stemcell transplantation, have improved the renal and overall prognosis for many of these disorders. © 2016 by the American Society of Nephrology.
Keywords: aged; disease course; multiple myeloma; kidney disease; hyperviscosity syndrome; stem cell transplantation; waldenstroem macroglobulinemia; immunofluorescence; biopsy; b-lymphocytes; kidney; physical examination; monoclonal immunoglobulinemia; proteinuria; paraproteinemia; fanconi syndrome; fanconi renotubular syndrome; kidney diseases; monoclonal gammopathy; monoclonal b cell lymphocytosis; humans; prognosis; human; article; paraproteins; mild renal impairment
Journal Title: Clinical Journal of the American Society of Nephrology
Volume: 11
Issue: 12
ISSN: 1555-9041
Publisher: American Society of Nephrology  
Date Published: 2016-12-07
Start Page: 2280
End Page: 2287
Language: English
DOI: 10.2215/cjn.02920316
PROVIDER: scopus
PMCID: PMC5142062
PUBMED: 27526705
DOI/URL:
Notes: Article -- Export Date: 2 August 2017 -- Source: Scopus
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