Authors: | Rosner, M. H.; Edeani, A.; Yanagita, M.; Glezerman, I. G.; Leung, N.; for the American Society of Nephrology Onco-Nephrology Forum |
Article Title: | Paraprotein-related kidney disease: Diagnosing and treating monoclonal gammopathy of renal significance |
Abstract: | Paraprotein-related kidney disease represents a complex group of diseases caused by an abnormal paraprotein secreted by a clone of B cells. The diseasemanifestations range from tubulopathies, such as the Fanconi syndrome, to a spectrum of glomerular diseases that can present with varying degrees of proteinuria and renal dysfunction. Diagnosis of these diseases can be challenging because of the wide range ofmanifestations as well as the relatively common finding of a serum paraprotein, especially in elderly patients. Thus, renal biopsy along with detailed hematologic workup is essential to link the presence of the paraprotein to the associated renal disease. Recent advances in treatment withmore effective and targeted chemotherapies, as well as stemcell transplantation, have improved the renal and overall prognosis for many of these disorders. © 2016 by the American Society of Nephrology. |
Keywords: | aged; disease course; multiple myeloma; kidney disease; hyperviscosity syndrome; stem cell transplantation; waldenstroem macroglobulinemia; immunofluorescence; biopsy; b-lymphocytes; kidney; physical examination; monoclonal immunoglobulinemia; proteinuria; paraproteinemia; fanconi syndrome; fanconi renotubular syndrome; kidney diseases; monoclonal gammopathy; monoclonal b cell lymphocytosis; humans; prognosis; human; article; paraproteins; mild renal impairment |
Journal Title: | Clinical Journal of the American Society of Nephrology |
Volume: | 11 |
Issue: | 12 |
ISSN: | 1555-9041 |
Publisher: | American Society of Nephrology |
Date Published: | 2016-12-07 |
Start Page: | 2280 |
End Page: | 2287 |
Language: | English |
DOI: | 10.2215/cjn.02920316 |
PROVIDER: | scopus |
PMCID: | PMC5142062 |
PUBMED: | 27526705 |
DOI/URL: | |
Notes: | Article -- Export Date: 2 August 2017 -- Source: Scopus |