Identification and targeting of kinase alterations in histiocytic neoplasms Journal Article


Authors: Ozkaya, N.; Dogan, A.; Abdel-Wahab, O.
Article Title: Identification and targeting of kinase alterations in histiocytic neoplasms
Abstract: Histiocytic disorders represent clonal disorders of cells believed to be derived from the monocyte, macrophage, and/or dendritic cell lineage presenting with a range of manifestations. Although their nature as clonal versus inflammatory nonclonal conditions have long been debated, recent studies identified numerous somatic mutations that activate mitogen-activated protein kinase signaling in clinically and histologically diverse forms of histiocytosis. Clinical trials and case series have revealed that targeting aberrant kinase signaling using BRAF and/or MEK inhibitors may be effective. These findings suggest that a personalized approach in which patient-specific alterations are identified and targeted may be a critically important therapeutic approach. © 2017 Elsevier Inc.
Keywords: unclassified drug; review; disease classification; drug efficacy; drug safety; nonhuman; neoplasm; proto oncogene; enzyme inhibition; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; enzyme activation; phosphatidylinositol 3 kinase; gene activation; hybrid protein; enzyme analysis; gene fusion; world health organization; histiocytosis; point mutation; mammalian target of rapamycin inhibitor; k ras protein; glutamic acid; phosphotransferase; b raf kinase; isoprotein; braf; mek; n ras protein; valine; mutant; langerhans cell histiocytosis; map kinase; molecular pathology; b raf kinase inhibitor; systemic disease; mitogen activated protein kinase kinase inhibitor; b raf gene; a raf kinase; human; priority journal; erdheim chester disease; erdheim-chester disease; histiocytic neoplasm; araf; a raf gene
Journal Title: Hematology/Oncology Clinics of North America
Volume: 31
Issue: 4
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 2017-08-01
Start Page: 705
End Page: 719
Language: English
DOI: 10.1016/j.hoc.2017.04.008
PROVIDER: scopus
PMCID: PMC5536849
PUBMED: 28673397
DOI/URL:
Notes: Review -- Export Date: 1 August 2017 -- Source: Scopus
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MSK Authors
  1. Ahmet Dogan
    194 Dogan
  2. Neval   Ozkaya
    19 Ozkaya