Quality of life among long-term survivors of advanced stage ovarian cancer: A cross-sectional approach Journal Article
| Authors: | Lutgendorf, S. K.; Shinn, E.; Carter, J.; Leighton, S.; Baggerly, K.; Guindani, M.; Fellman, B.; Matzo, M.; Slavich, G. M.; Goodman, M. T.; Tew, W.; Lester, J.; Moore, K. M.; Karlan, B. Y.; Levine, D. A.; Sood, A. K. |
| Article Title: | Quality of life among long-term survivors of advanced stage ovarian cancer: A cross-sectional approach |
| Abstract: | Purpose Long-term survival of women with advanced-stage ovarian cancer is relatively rare. Little is known about quality of life (QOL) and survivorship concerns of these women. Here, we describe QOL of women with advanced-stage ovarian cancer surviving for 8.5 years or longer and compare women with 0–1 recurrence to those with multiple recurrences. Methods Participants (n = 56) recruited from 5 academic medical centers and the Ovarian Cancer Research Fund Alliance completed surveys regarding QOL (FACT-O), mood (CESD), social support (SPS), physical activity (IPAQ-SF), diet, and clinical characteristics. Median survival was 14.0 years (range 8.8–33.3). Results QOL and psychological adjustment of long-term survivors was relatively good, with mean FACT-G scores (multiple recurrences: 80.81 ± 13.95; 0–1 recurrence: 89.05 ± 10.80) above norms for healthy community samples (80.1 ± 18.1). Survivors with multiple recurrences reported more compromised QOL in domains of physical and emotional well-being (p < .05), and endorsed a variety of physical and emotional concerns compared to survivors with 0–1 recurrence. Difficulties in sexual functioning were common in both groups. Almost half (43%) of the survivors reported low levels of physical activity. Conclusions Overall, women with advanced-stage ovarian cancer who have survived at least 8.5 years report good QOL and psychological adjustment. QOL of survivors with multiple recurrences is somewhat impaired compared to those with 0–1 recurrence. Limitations include a possible bias towards participation by healthier survivors, thus under-representing the level of compromise in long-term survivors. Health care practitioners should be alert to psychosocial issues faced by these long-term survivors to provide interventions that enhance QOL. © 2017 Elsevier Inc. |
| Keywords: | adult; cancer survival; controlled study; aged; disease-free survival; middle aged; survival rate; major clinical study; cancer recurrence; advanced cancer; comparative study; disease free survival; cancer staging; neoplasm staging; neoplasm; ovarian cancer; ovarian neoplasms; quality of life; ovary cancer; neoplasm recurrence, local; psychology; health survey; pathology; diet supplementation; survivor; cancer survivor; survivors; social support; mood; sexuality; tumor recurrence; ovary tumor; long term care; recurrent disease; cross-sectional study; cross-sectional studies; physical activity; lifestyle modification; university hospital; social psychology; psychometrics; psychometry; psychological adjustment; lifestyle; life style; neoplasms, glandular and epithelial; psychosocial; center for epidemiological studies depression scale; mood change; social interaction; dyadic adjustment scale; long-term survivor; quality of life assessment; long term survival; humans; human; female; priority journal; article; psychological well-being; abbreviated dyadic adjustment scale; functional assessment of cancer therapy ovarian; international physical activity questionnaire; psychological well being scale |
| Journal Title: | Gynecologic Oncology |
| Volume: | 146 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-07-01 |
| Start Page: | 101 |
| End Page: | 108 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2017.05.008 |
| PUBMED: | 28527672 |
| PROVIDER: | scopus |
| PMCID: | PMC5618102 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2017 -- Source: Scopus |
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