The role of therapeutic layering in optimizing treatment for patients with castration-resistant prostate cancer (prostate cancer radiographic assessments for detection of advanced recurrence II) Journal Article


Authors: Crawford, E. D.; Petrylak, D. P.; Shore, N.; Saad, F.; Slovin, S. F.; Vogelzang, N. J.; Keane, T. E.; Koo, P. J.; Gomella, L. G.; O'Sullivan, J. M.; Tombal, B.; Concepcion, R. S.; Sieber, P.; Stone, N. N.; Finkelstein, S. E.; Yu, E. Y.; as the Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence (RADAR II) Group
Article Title: The role of therapeutic layering in optimizing treatment for patients with castration-resistant prostate cancer (prostate cancer radiographic assessments for detection of advanced recurrence II)
Abstract: Objective To offer recommendations on identification of disease progression, treatment management strategies, and suggestions on timing of initiating and discontinuing specific castration-resistant prostate cancer (CRPC) treatments. Materials and Methods The Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence II Working Group convened to provide guidance on sequencing, combination, or layering of approved treatments for metastatic CRPC based on available data and clinical experience. Results A consensus was developed to address important questions on management of patients with metastatic CRPC. Conclusion In the absence of large-scale clinical trials, the Working Group recommends that patients may best be managed with a layered approach of approved therapies with unique or complimentary mechanisms of action. © 2017 Elsevier Inc.
Keywords: cancer chemotherapy; cancer recurrence; cancer growth; multimodality cancer therapy; cancer diagnosis; cancer immunotherapy; consensus; computer assisted tomography; questionnaire; antineoplastic hormone agonists and antagonists; castration resistant prostate cancer; photon emission tomography; abiraterone; sipuleucel t; enzalutamide; human; male; priority journal; article
Journal Title: Urology
Volume: 104
ISSN: 0090-4295
Publisher: Elsevier Science, Inc.  
Date Published: 2017-06-01
Start Page: 150
End Page: 159
Language: English
DOI: 10.1016/j.urology.2016.12.033
PROVIDER: scopus
PUBMED: 28302580
DOI/URL:
Notes: Article -- Export Date: 3 July 2017 -- Source: Scopus
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MSK Authors
  1. Susan Slovin
    184 Slovin