The role of therapeutic layering in optimizing treatment for patients with castration-resistant prostate cancer (prostate cancer radiographic assessments for detection of advanced recurrence II) Journal Article
| Authors: | Crawford, E. D.; Petrylak, D. P.; Shore, N.; Saad, F.; Slovin, S. F.; Vogelzang, N. J.; Keane, T. E.; Koo, P. J.; Gomella, L. G.; O'Sullivan, J. M.; Tombal, B.; Concepcion, R. S.; Sieber, P.; Stone, N. N.; Finkelstein, S. E.; Yu, E. Y.; as the Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence (RADAR II) Group |
| Article Title: | The role of therapeutic layering in optimizing treatment for patients with castration-resistant prostate cancer (prostate cancer radiographic assessments for detection of advanced recurrence II) |
| Abstract: | Objective To offer recommendations on identification of disease progression, treatment management strategies, and suggestions on timing of initiating and discontinuing specific castration-resistant prostate cancer (CRPC) treatments. Materials and Methods The Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence II Working Group convened to provide guidance on sequencing, combination, or layering of approved treatments for metastatic CRPC based on available data and clinical experience. Results A consensus was developed to address important questions on management of patients with metastatic CRPC. Conclusion In the absence of large-scale clinical trials, the Working Group recommends that patients may best be managed with a layered approach of approved therapies with unique or complimentary mechanisms of action. © 2017 Elsevier Inc. |
| Keywords: | cancer chemotherapy; cancer recurrence; cancer growth; multimodality cancer therapy; cancer diagnosis; cancer immunotherapy; consensus; computer assisted tomography; questionnaire; antineoplastic hormone agonists and antagonists; castration resistant prostate cancer; photon emission tomography; abiraterone; sipuleucel t; enzalutamide; human; male; priority journal; article |
| Journal Title: | Urology |
| Volume: | 104 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2017-06-01 |
| Start Page: | 150 |
| End Page: | 159 |
| Language: | English |
| DOI: | 10.1016/j.urology.2016.12.033 |
| PROVIDER: | scopus |
| PUBMED: | 28302580 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
