Stem cells, cancer, and MUSASHI in blood and guts Journal Article
| Authors: | Kharas, M. G.; Lengner, C. J. |
| Article Title: | Stem cells, cancer, and MUSASHI in blood and guts |
| Abstract: | The mammalian MSI family of RNA-binding proteins (RBPs) have important roles as oncoproteins in an array of tumor types, including leukemias, glioblastomas, and pancreatic, breast, lung, and colorectal cancers. The mammalian Msi genes, Msi1 and Msi2, have been most thoroughly investigated in two highly proliferative tissues prone to oncogenic transformation: the hematopoietic lineage and the intestinal epithelium. Despite their vast phenotypic differences, MSI proteins appear to have an analogous role in governing the stem cell compartment in both of these tissues, potentially providing a paradigm for a broader understanding of MSI function and oncogenic activities. In this review, we focus on the function of MSI in the blood and the intestine, and discuss therapeutic strategies for targeting this pathway. © 2017 Elsevier Inc. |
| Keywords: | review; nonhuman; colorectal cancer; gene; gene targeting; gene expression; gene function; stem cell; blood; stem cells; hematopoietic stem cell; rna processing; intestine; cancer stem cells; columnar epithelium; digestive system; cancer; human; priority journal; malignant neoplasm; rna binding proteins; hematopoietic system malignancy; msi gene |
| Journal Title: | Trends in Cancer |
| Volume: | 3 |
| Issue: | 5 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2017-05-01 |
| Start Page: | 347 |
| End Page: | 356 |
| Language: | English |
| DOI: | 10.1016/j.trecan.2017.03.007 |
| PROVIDER: | scopus |
| PMCID: | PMC5546142 |
| PUBMED: | 28718412 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 July 2017 -- Source: Scopus |
