Independent prognostic significance of monosomy 17 and impact of karyotype complexity in monosomal karyotype/complex karyotype acute myeloid leukemia: Results from four ECOG-ACRIN prospective therapeutic trials Journal Article
| Authors: | Strickland, S. A.; Sun, Z.; Ketterling, R. P.; Cherry, A. M.; Cripe, L. D.; Dewald, G.; Fernandez, H. F.; Hicks, G. A.; Higgins, R. R.; Lazarus, H. M.; Litzow, M. R.; Luger, S. M.; Paietta, E. M.; Rowe, J. M.; Vance, G. H.; Wiernik, P.; Wiktor, A. E.; Zhang, Y.; Tallman, M. S.; on behalf of the ECOGACRIN Cancer Research Group |
| Article Title: | Independent prognostic significance of monosomy 17 and impact of karyotype complexity in monosomal karyotype/complex karyotype acute myeloid leukemia: Results from four ECOG-ACRIN prospective therapeutic trials |
| Abstract: | The presence of a monosomal karyotype (MK+) and/or a complex karyotype (CK+) identifies subcategories of AML with poor prognosis. The prognostic significance of the most common monosomies (monosomy 5, monosomy 7, and monosomy 17) within MK+/CK+ AML is not well defined. We analyzed data from 1,592 AML patients age 17–93 years enrolled on ECOG-ACRIN therapeutic trials. The majority of MK+ patients (182/195; 93%) were MK+/CK+ with 87% (158/182) having ≥5 clonal abnormalities (CK≥ 5). MK+ patients with karyotype complexity ≤4 had a median overall survival (OS) of 0.4y compared to 1.0y for MK- with complexity ≤4 (p < 0.001), whereas no OS difference was seen in MK+ vs. MK- patients with CK≥ 5 (p = 0.82). Monosomy 5 (93%; 50/54) typically occurred within a highly complex karyotype and had no impact on OS (0.4y; p = 0.95). Monosomy 7 demonstrated no impact on OS in patients with CK≥ 5 (p = 0.39) or CK ≤ 4 (p = 0.44). Monosomy 17 appeared in 43% (68/158) of CK≥ 5 patients and demonstrated statistically significant worse OS (0.4y) compared to CK≥ 5 patients without monosomy 17 (0.5y; p = 0.012). Our data suggest that the prognostic impact of MK+ is limited to those with less complex karyotypes and that monosomy 17 may independently predict for worse survival in patients with AML. © 2017 Elsevier Ltd |
| Keywords: | cytogenetics; myeloid leukemia; complex karyotype; monosomy 7; prognosis; monosomal karyotype; monosomy 17; monosomy 5 |
| Journal Title: | Leukemia Research |
| Volume: | 59 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2017-08-01 |
| Start Page: | 55 |
| End Page: | 64 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2017.05.010 |
| PROVIDER: | scopus |
| PUBMED: | 28551161 |
| PMCID: | PMC5573653 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
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