Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis Journal Article
| Authors: | Rennert, R. C.; Hoshide, R. R.; Signorelli, J. W.; Amaro, D.; Sack, J. A.; Brennan, C. W.; Chen, C. C. |
| Article Title: | Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis |
| Abstract: | The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature. © AANS, 2017. |
| Keywords: | metastasis; oncology; glioblastoma; chromothripsis |
| Journal Title: | Journal of Neurosurgery |
| Volume: | 126 |
| Issue: | 5 |
| ISSN: | 0022-3085 |
| Publisher: | American Association of Neurological Surgeons |
| Date Published: | 2017-05-01 |
| Start Page: | 1472 |
| End Page: | 1478 |
| Language: | English |
| DOI: | 10.3171/2016.4.jns153052 |
| PROVIDER: | scopus |
| PUBMED: | 27447440 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
