Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis Journal Article


Authors: Rennert, R. C.; Hoshide, R. R.; Signorelli, J. W.; Amaro, D.; Sack, J. A.; Brennan, C. W.; Chen, C. C.
Article Title: Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis
Abstract: The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature. © AANS, 2017.
Keywords: metastasis; oncology; glioblastoma; chromothripsis
Journal Title: Journal of Neurosurgery
Volume: 126
Issue: 5
ISSN: 0022-3085
Publisher: American Association of Neurological Surgeons  
Date Published: 2017-05-01
Start Page: 1472
End Page: 1478
Language: English
DOI: 10.3171/2016.4.jns153052
PROVIDER: scopus
PUBMED: 27447440
DOI/URL:
Notes: Article -- Export Date: 3 July 2017 -- Source: Scopus
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  1. Cameron Brennan
    151 Brennan