| Abstract: |
Extended lymphadenectomy has been shown to be associated with improved survival for node-negative gastric cancer patients. 247 patients adenocarcinoma at Memorial Sloan-Kettering Cancer Center (MSKCC) were identified with histologically negative lymph nodes by hematoxylin-esosin staining and form the basis of this study. Survival was analyzed by extent of lymphadenectomy, stratified by T stage. The extent of lymph node dissection did not predict survival over the entire cohort. However, when stratified For T stage, D2 dissection offered a survival advantage for T3 tumors. Overall, we demonstrate that D2 dissection was associated with improved survival for advanced T stage, node negative gastric cancer. These data offer a strong argument to perform routine D2 dissection for gastric carcinoma with advanced primaries in the absence of obvious gross nodal metastasis. |
