The protein kinase c (PKC) inhibitor flavopiridol (FLAVO) significantly enhances the cytotoxic effect of chemotherapy by promoting apoptosis in gastric cancer cells Conference Paper
| Authors: | Schwartz, G. K.; Farsi, D.; Greaney, C.; Werner, J.; Kelsen, D. K. |
| Editors: | Siewert, J. R.; Roder, J. D. |
| Title: | The protein kinase c (PKC) inhibitor flavopiridol (FLAVO) significantly enhances the cytotoxic effect of chemotherapy by promoting apoptosis in gastric cancer cells |
| Conference Title: | 2nd International Gastric Cancer Congress |
| Abstract: | The failure of many chemotherapeutic agents in gastric tumors reflects an inability of these drugs to induce apoptosis. Even with high concentrations of paclitaxel and mitomycin-C (MMC), MKN-74 gastric cancer cells lines are resistant to the induction of apoptosis. We are able to show that flavopiridol, a synthetic flavone, significantly enhances the induction of apoptosis by paclitaxel and MMC in MKN-74 treated cells. |
| Journal Title | Progress in Gastric Cancer Research 1997: Proceedings of the 2nd International Gastric Cancer Congress |
| Conference Dates: | 1997 Apr 27-30 |
| Conference Location: | Munich, Germany |
| ISBN: | 9788832304275 |
| Publisher: | Monduzzi Editore |
| Location: | Bologna, Italy |
| Date Published: | 1997-01-01 |
| Start Page: | 627 |
| End Page: | 629 |
| Language: | English |
| ACCESSION: | WOS:A1997BJ02Q00118 |
| PROVIDER: | wos |
| Notes: | Proceedings Paper -- Source: Wos |
