CT-based dosimetry for transperineal I-125 prostate brachytherapy Journal Article
| Authors: | Willins, J.; Wallner, K. |
| Article Title: | CT-based dosimetry for transperineal I-125 prostate brachytherapy |
| Abstract: | Purpose: To demonstrate CT-based target coverage achieved by an experienced brachytherapy team, with a documented history of clinical efficacy, These results may serve as a point of reference by which other implant teams could evaluate their technical results. Methods and Materials: Two to 4 h after implantation, a CT scan of the pelvis was obtained, taking 3-mm thick images at 3 mm scan intervals, The outer margins of the rectum and prostate were outlined on each CT section by a single investigator (KW), CT scans from 20 consecutive, unselected patients with stage T1 or T2 prostatic carcinoma who had transperineal I-125 implants at MSKCC in 1995 were analyzed, The prescribed minimum peripheral prostate dose was 140 Gy, based on a preimplant CT scan of the prostate, Target volumes were determined based on planar reconstruction of the prostate. Results: An average of 84% of the target (range: 76-92%) was covered by the 140 Gy isodose line, An average of 90% of the target (range: 81-96%) was covered by the 120 Gy isodose line, The average minimum target dose was 57 Gy (range: 40-70 Gy), There was a loose correlation between the minimum dose and the degree of target coverage (r = 0.33). Conclusions: Based on CT scanning on the day of the implant, coverage of 80% or more of the target volume by the prescription dose is probably adequate, Accurate evaluation is a complex problem that is made imprecise by difficulty in target identification and by volume changes after the implant. (C) 1997 Elsevier Science Inc. |
| Keywords: | dosimetry; carcinoma; brachytherapy; implantation; prostatic carcinoma |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 39 |
| Issue: | 2 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-09-01 |
| Start Page: | 347 |
| End Page: | 353 |
| Language: | English |
| ACCESSION: | WOS:A1997XV96900012 |
| DOI: | 10.1016/s0360-3016(97)00322-2 |
| PROVIDER: | wos |
| PUBMED: | 9308938 |
| Notes: | Article -- Source: Wos |
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