Structure, recognition and adaptive binding in RNA aptamer complexes Journal Article

  


Authors: Patel, D. J.; Suri, A. K.; Jiang, F.; Jiang, L.; Fan, P.; Kumar, R. A.; Nonin, S.
Article Title: Structure, recognition and adaptive binding in RNA aptamer complexes
Abstract: Novel features of RNA structure, recognition and discrimination have been recently elucidated through the solution structural characterizion of RNA aptamers that bind cofactors, aminoglycoside antibiotics, amino acids and peptides with high affinity and specificity. This review presents the solution structures of RNA aptamer complexes with adenosine monophosphate, flavin mononucleotide, arginine/citrulline and tobramycin together with an example of hydrogen exchange measurements of the base-pair kinetics for the AMP-RNA aptamer complex. A comparative analysis of the structures of these RNA aptamer complexes yields the principles, patterns and diversity associated with RNA architecture, molecular recognition and adaptive binding associated with complex formation.
Keywords: binding affinity; proteins; complex formation; peptide; rna; molecular recognition; magnetic resonance spectroscopy; short survey; amino acid; models, molecular; nucleic acid conformation; rna structure; tobramycin; ligand binding; arginine; rna binding; oligonucleotides; flavine mononucleotide; flavin mononucleotide; adenosine phosphate; protein rna binding; adenosine monophosphate; chemical reaction kinetics; aminoglycoside antibiotic agent; rna conformation; oligoribonucleotide; citrulline; priority journal; cofactor; rna aptamer complexes; amino acid and aminoglycoside antibiotic ligands; nmr based solution structures; sequence specific recognition and discrimination
Journal Title: Journal of Molecular Biology
Volume: 272
Issue: 5
ISSN: 0022-2836
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 1997-10-10
Start Page: 645
End Page: 664
Language: English
DOI: 10.1006/jmbi.1997.1281
PUBMED: 9368648
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031563817&doi=10.1006%2fjmbi.1997.1281&partnerID=40&md5=5c21f87c0a3a54fd4430d5af1071df7c
Notes: Short Survey -- Export Date: 17 March 2017 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Feng Jiang
    13 Jiang
  2. Dinshaw J Patel
    477 Patel
  3. Pang-Dian Fan
    15 Fan
  4. Asif K Suri
    6 Suri
  5. Rakesh Ajay Kumar
    12 Kumar
Related MSK Work