Acid sphingomyelinase Journal Article
| Authors: | Henry, B.; Ziobro, R.; Becker, K. A.; Kolesnick, R.; Gulbins, E. |
| Article Title: | Acid sphingomyelinase |
| Abstract: | The enzyme acid sphingomyelinase catalyzes the hydrolysis of sphingomyelin to ceramide. The importance of the enzyme for cell functions was first recognized in Niemann-Pick disease type A and B, the genetic disorders with a massive accumulation of sphingomyelin in many organs. Studies in the last years demonstrated that the enzyme also has an important role in cell signalling. Thus, the acid sphingomyelinase has a central function for the re-organization of molecules within the cell upon stimulation and thereby for the response of cells to stress and the induction of cell death but also proliferation and differentiation. Here, we discuss the current state of the art of the structure, regulation, and function of the acid sphingomyelinase. © Springer-Verlag Wien 2013. |
| Keywords: | signal transduction; review; nonhuman; cell proliferation; animal; animals; cell death; cell function; cell differentiation; enzyme activation; enzyme activity; physiology; chemistry; enzyme regulation; catalysis; enzyme structure; hydrolysis; bioaccumulation; cell stress; ceramide; sphingomyelin phosphodiesterase; intracellular signaling; sphingomyelin; acid sphingomyelinase; niemann pick disease; membrane domains; humans; human; priority journal; article |
| Journal Title: | Handbook of Experimental Pharmacology |
| Volume: | 215 |
| ISSN: | 0171-2004 |
| Publisher: | Springer |
| Date Published: | 2013-01-01 |
| Start Page: | 77 |
| End Page: | 88 |
| Language: | English |
| DOI: | 10.1007/978-3-7091-1368-4_4 |
| PUBMED: | 23579450 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter in 'Sphingolipids: Basic Science and Drug Development" (ISBN: 978-3-7091-1367-7) -- Article -- Export Date: 5 June 2017 -- Source: Scopus |
