Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses Journal Article

   


Authors: Lavin, Y.; Kobayashi, S.; Leader, A.; Amir, E. A. D.; Elefant, N.; Bigenwald, C.; Remark, R.; Sweeney, R.; Becker, C. D.; Levine, J. H.; Meinhof, K.; Chow, A.; Kim-Shulze, S.; Wolf, A.; Medaglia, C.; Li, H.; Rytlewski, J. A.; Emerson, R. O.; Solovyov, A.; Greenbaum, B. D.; Sanders, C.; Vignali, M.; Beasley, M. B.; Flores, R.; Gnjatic, S.; Pe'er, D.; Rahman, A.; Amit, I.; Merad, M.
Article Title: Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses
Abstract: To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single-cell analysis of the tumor, non-involved lung, and blood cells, we provide a detailed immune cell atlas of early lung tumors. We show that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments. Moreover, we identified changes in tumor-infiltrating myeloid cell (TIM) subsets that likely compromise anti-tumor T cell immunity. Paired single-cell analyses thus offer valuable knowledge of tumor-driven immune changes, providing a powerful tool for the rational design of immune therapies. Video Abstract © 2017 Elsevier Inc.
Keywords: lung adenocarcinoma; t cell; tls; nk cell; immune cell atlas; cd141+ dc; cd1c+ dc; human non-small cell lung cancer (nsclc); tim; tumor macrophage
Journal Title: Cell
Volume: 169
Issue: 4
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2017-05-04
Start Page: 750
End Page: 765.e17
Language: English
DOI: 10.1016/j.cell.2017.04.014
PROVIDER: scopus
PUBMED: 28475900
PMCID: PMC5737939
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018766073&doi=10.1016%2fj.cell.2017.04.014&partnerID=40&md5=553594fbe9a30c1bbcc7762e885674d8
Notes: Article -- Export Date: 2 June 2017 -- Source: Scopus
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MSK Authors
  1. Jacob H Levine
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  2. Dana Pe'er
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