Neoadjuvant hormonal therapy plus surgery for prostate cancer: The MSKCC experience Journal Article
| Authors: | Fair, W. R.; Scher, H. I. |
| Article Title: | Neoadjuvant hormonal therapy plus surgery for prostate cancer: The MSKCC experience |
| Abstract: | This article reviews the current status of neoadjuvant hormonal therapy (NHT) in the treatment of clinically localized prostate cancer. Although significant increases in the organ confined rate and similar marked decreases in the positive margin rate are found in patients receiving NHT, to date no difference in disease free survival rate, as determined by PSA values, can be shown. However, there is a suggestion (P = <0.06) of an improved disease- free survival in patients with an initial PSA > 10 ng/ml when treated with NHT compared with controls. Given the prolonged natural history of prostate cancer, longer follow-up will be required before the value of NHT can be established. |
| Keywords: | cancer survival; treatment outcome; disease-free survival; middle aged; survival rate; review; cancer recurrence; cancer adjuvant therapy; chemotherapy, adjuvant; follow-up studies; neoplasm staging; polymerase chain reaction; prostate specific antigen; metastasis; cancer hormone therapy; prostate cancer; prostate-specific antigen; prostatic neoplasms; goserelin; randomized controlled trials; prostatectomy; forecasting; diethylstilbestrol; flutamide; castration; antineoplastic agents, hormonal; transrectal ultrasonography; clinical trials; neoplasm circulating cells; clinical trials, phase iii; humans; prognosis; human; male |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-10-01 |
| Start Page: | 831 |
| End Page: | 846 |
| Language: | English |
| PUBMED: | 9309096 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
