Neoadjuvant therapy of esophageal cancer Journal Article
| Authors: | Ilson, D. H.; Bains, M.; Ginsberg, R. J.; Kelsen, D. P. |
| Article Title: | Neoadjuvant therapy of esophageal cancer |
| Abstract: | Locally advanced esophageal cancer, potentially curable with surgery or radiotherapy-based treatment, has a poor prognosis because of the eventual development of systemic metastatic disease in the majority of patients. Local recurrence of disease after local treatment modalities is equally problematic. The use of systemic chemotherapy in the surgical and radiation- based treatment of esophageal cancer is reviewed, including the approach of preoperative chemotherapy, preoperative concurrent chemotherapy plus radiotherapy, and chemoradiotherapy as definitive treatment without surgery. The use of chemoradiotherapy has clearly been shown to be superior to radiotherapy alone in the nonsurgical management of locoregional esophageal cancer. Recent trials suggest that preoperative chemoradiotherapy may be superior to surgery alone but trials are ongoing to better define the role of combined modality therapy in the surgical management of esophageal cancer. |
| Keywords: | cancer chemotherapy; survival rate; review; cancer recurrence; cisplatin; doxorubicin; fluorouracil; diarrhea; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; preoperative care; chemotherapy, adjuvant; combined modality therapy; radiotherapy, adjuvant; carboplatin; metastasis; neoplasm recurrence, local; bone marrow suppression; etoposide; mucosa inflammation; antineoplastic combined chemotherapy protocols; radiotherapy dosage; antineoplastic activity; folinic acid; neoplasm metastasis; bleomycin; forecasting; vindesine; preoperative treatment; mitomycin; esophagus cancer; clinical trials; esophageal neoplasms; humans; prognosis; human |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-10-01 |
| Start Page: | 723 |
| End Page: | 740 |
| Language: | English |
| PUBMED: | 9309090 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
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