Topotecan and the treatment of recurrent ovarian cancer: Is there a role for granulocyte colony-stimulating factor? Journal Article
| Authors: | Saltz, L.; Janik, J. E. |
| Article Title: | Topotecan and the treatment of recurrent ovarian cancer: Is there a role for granulocyte colony-stimulating factor? |
| Abstract: | Topotecan (Hycamtin; SmithKline Beecham Pharmaceuticals, Philadelphia, PA) a new chemotherapeutic agent for the treatment of patients with advanced carcinoma of the ovary after failure of initial or subsequent therapy, is a specific, potent inhibitor of the enzyme topoisomerase I. Myelosuppression is the dose-limiting toxicity of topotecan, and can interfere with the administration of the recommended dose/schedule of the drug by delaying the next cycle of chemotherapy or by requiring a reduction in the dose. The results from clinical studies suggest that routine granulocyte colony-stimulating factor therapy is not needed when topotecan is administered at the recommended dose of 1.5 mg/m2/d for 5 days. However, patients should be carefully monitored, as some may benefit from hematopoietic growth factor support on subsequent cycles. |
| Keywords: | clinical trial; neutropenia; review; dose response; antineoplastic agents; topotecan; antineoplastic agent; ovarian neoplasms; neoplasm recurrence, local; bone marrow; drug administration schedule; camptothecin; drug effect; dose-response relationship, drug; enzyme inhibitor; drug antagonism; enzyme inhibitors; chemically induced disorder; tumor recurrence; ovary tumor; drug derivative; drug administration; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; clinical trials; dna topoisomerase; dna topoisomerases, type i; humans; human; female |
| Journal Title: | Seminars in Oncology |
| Volume: | 24 |
| Issue: | 1 Suppl. 5 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-02-01 |
| Start Page: | S5-26 |
| End Page: | S5-30 |
| Language: | English |
| PUBMED: | 9122740 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
