Advances in Kaposi's sarcoma Journal Article
| Authors: | Myskowski, P. L.; Ahkami, R. |
| Article Title: | Advances in Kaposi's sarcoma |
| Abstract: | KS remains a challenge to clinicians and investigators more than a century after its initial description. Debate continues as to the cell of origin, as well as whether or not it is a true cancer. KS appears to be an opportunistic neoplasm, which in its earliest phase retains some features of a benign hyperproliferative process, but in its late stages behaves like an aggressive malignancy. Pathogenesis seems to involve a predisposed individual (genetically susceptible or immunologically compromised) who comes into contact with an infectious agent, most likely a virus. Cytokines appear to play a major role in the growth of the tumor. The exact role of the KSHV in this process will likely be the subject of much investigation in the future. |
| Keywords: | pathogenesis; review; interferon; cancer diagnosis; disease association; gene expression; skin neoplasms; palliative therapy; antineoplastic activity; angiogenesis; cytokine; herpes virus; interleukin 6; forecasting; antivirus agent; kaposi sarcoma; sarcoma, kaposi; evaluation studies; immunosuppressive treatment; retinoid; clinical trials; antiviral activity; zidovudine; fumagillol chloroacetylcarbamate; interleukin 1; tecogalan; humans; priority journal; thrombocyte factor |
| Journal Title: | Dermatologic Clinics |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 0733-8635 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 1997-01-01 |
| Start Page: | 177 |
| End Page: | 188 |
| Language: | English |
| DOI: | 10.1016/s0733-8635(05)70424-1 |
| PUBMED: | 9001870 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
