The biological therapy of acute and chronic leukemia Journal Article
| Authors: | Caron, P. C.; Scheinberg, D. A. |
| Article Title: | The biological therapy of acute and chronic leukemia |
| Abstract: | With the increasing knowledge of the mechanisms of immune-mediated cytotoxicity, immunotherapeutic strategies are rapidly being incorporated into chemotherapy treatment schemes for acute and chronic leukemias. This includes the use of mAbs, immunotoxins, tumor-specific T cells, and, most recently, vaccines. Much of the new information is derived from bone marrow transplant data, where immune enhancement from IL-2 and donor T-cell infusions are being studied. Trials using humanized mAbs that permit prolonged and repeated dosing will allow better evaluation of the effectiveness of mAb therapy. More sophisticated molecular tests have been developed, allowing the detection of minimal residual disease to a greater degree. It is likely that biological and immunological therapy of leukemia will have its greatest impact here. |
| Keywords: | cancer chemotherapy; leukemia; unclassified drug; fludarabine; clinical trial; review; interleukin 2; cancer immunotherapy; monoclonal antibody; chronic disease; acute leukemia; immunotherapy; cancer vaccine; minimal residual disease; blood transfusion; graft versus host reaction; immunomodulation; immunomodulating agent; biological therapy; retinoic acid; alemtuzumab; acute disease; cd33 antigen; cladribine; autologous bone marrow transplantation; myeloid leukemia; leukemia antigen; antibody conjugate; bone marrow purging; immunotoxin; chronic leukemia; monoclonal antibody m 195; lymphokine activated killer cell; humans; human; priority journal; monoclonal antibody aml 2 23; monoclonal antibody bc 8; monoclonal antibody p 67; monoclonal antibody pm 81; monoclonal antibody pmn 29; monoclonal antibody pmn 6; monoclonal antibody t 101 |
| Journal Title: | Cancer Investigation |
| Volume: | 15 |
| Issue: | 4 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1997-01-01 |
| Start Page: | 342 |
| End Page: | 352 |
| Language: | English |
| PUBMED: | 9246157 |
| PROVIDER: | scopus |
| DOI: | 10.3109/07357909709039738 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
