Dosimetric and workflow evaluation of first commercial synthetic CT software for clinical use in pelvis Journal Article
| Authors: | Tyagi, N.; Fontenla, S.; Zhang, J.; Cloutier, M.; Kadbi, M.; Mechalakos, J.; Zelefsky, M.; Deasy, J.; Hunt, M. |
| Article Title: | Dosimetric and workflow evaluation of first commercial synthetic CT software for clinical use in pelvis |
| Abstract: | To evaluate a commercial synthetic CT (syn-CT) software for use in prostate radiotherapy. Twenty-five prostate patients underwent CT and MR simulation scans in treatment position on a 3T MR scanner. A commercially available MR protocol was used that included a T2w turbo spin-echo sequence for soft-tissue contrast and a dual echo 3D mDIXON fast field echo (FFE) sequence for generating syn-CT. A dual-echo 3D FFE B 0 map was used for patient-induced susceptibility distortion analysis and a new 3D balanced-FFE sequence was evaluated for identification of implanted gold fiducial markers and subsequent image-guidance during radiotherapy delivery. Tissues were classified as air, adipose, water, trabecular/spongy bone and compact/cortical bone and assigned bulk HU values. The accuracy of syn-CT for treatment planning was analyzed by transferring the structures and plan from planning CT to syn-CT and recalculating the dose. Accuracy of localization at the treatment machine was evaluated by comparing registration of kV radiographs to either digitally reconstructed radiographs (DRRs) generated from syn-CT or traditional DRRs generated from the planning CT. Similarly, accuracy of setup using CBCT and syn-CT was compared to that using the planning CT. Finally, a MR-only simulation workflow was established and end-to-end testing was completed on five patients undergoing MR-only simulation. Dosimetric comparison between the original CT and syn-CT plans was within 0.5% on average for all structures. The de-novo optimized plans on the syn-CT met institutional clinical objectives for target and normal structures. Patient-induced susceptibility distortion based on B 0 maps was within 1 mm and 0.5 mm in the body and prostate respectively. DRR and CBCT localization based on MR-localized fiducials showed a standard deviation of <1 mm. End-to-end testing and MR simulation workflow was successfully validated. MRI derived synthetic CT can be successfully used for a MR-only planning and treatment for prostate radiotherapy. © 2017 Institute of Physics and Engineering in Medicine. |
| Keywords: | treatment planning; radiotherapy; prostate cancer; computerized tomography; dosimetry; urology; bone; radiography; patient treatment; prostate cancers; diseases; tissue; standard deviation; prostate radiotherapy; clinical workflow; mrcat; synthetic ct; digitally reconstructed radiographs; distortion analysis |
| Journal Title: | Physics in Medicine and Biology |
| Volume: | 62 |
| Issue: | 8 |
| ISSN: | 0031-9155 |
| Publisher: | IOP Publishing Ltd |
| Date Published: | 2017-04-21 |
| Start Page: | 2961 |
| End Page: | 2975 |
| Language: | English |
| DOI: | 10.1088/1361-6560/aa5452 |
| PROVIDER: | scopus |
| PUBMED: | 27983520 |
| PMCID: | PMC5541676 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2017 -- Source: Scopus |
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