Role of posttranslational modifications in replication initiation Book Section

  


Authors: Wei, L.; Zhao, X.
Editor: Kaplan, D. L.
Article/Chapter Title: Role of posttranslational modifications in replication initiation
Abstract: DNA replication must occur precisely once per cell cycle to maintain a stable genome. An important means to achieve this is through multilayered regulation of replication initiation at both local and global levels. Recent genetic and biochemical studies in several organisms have revealed critical roles of posttranslational modifications (PTMs) in these regulations. While the best-demonstrated class of PTMs is kinase-mediated phosphorylation, additional forms of PTMs including ubiquitylation, methylation, and acetylation also contribute to the control of replication initiation. Here we survey the current understanding of how different types of modifications govern and fine-tune several aspects of replication initiation, including origin licensing, firing, and global replication timing. © 2016 Springer International Publishing Switzerland.
Keywords: methylation; phosphorylation; acetylation; ubiquitylation; posttranslational modifications; dna replication initiation; origin firing; origin licensing; replication timing
Book Title: The Initiation of DNA Replication in Eukaryotes
ISBN: 978-3-319-24694-9
Publisher: Springer  
Publication Place: Cham, Switzerland
Date Published: 2016-01-01
Start Page: 371
End Page: 392
Language: English
DOI: 10.1007/978-3-319-24696-3_18
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017061195&doi=10.1007%2f978-3-319-24696-3_18&partnerID=40&md5=5d207814e2fbc84ef88f5ee3c85441eb
Notes: Book Chapter: 18 -- Export Date: 2 May 2017 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Xiaolan Zhao
    77 Zhao
  2. Lei Wei
    11 Wei
Related MSK Work