Alternative Pre-mRNA splicing of mu opioid receptor gene: Molecular mechanisms underlying the complex actions of mu opioids Book Section


Author: Pan, Y. X.
Editors: Belfer, I.; Diatchenko, L.
Article/Chapter Title: Alternative Pre-mRNA splicing of mu opioid receptor gene: Molecular mechanisms underlying the complex actions of mu opioids
Abstract: The μ-opioid receptor (MOR) plays a fundamental role in mediating the actions of morphine and most clinical analgesic agents, as well as drugs of abuse such as heroin. Clinically, patients often display diverse responses toward various mu opioids, including analgesia, tolerance, and side effects, such as constipation, itch, and addiction. Alternative pre-mRNA splicing is a major mechanism for creating protein isoform diversity. Alternative pre-mRNA splicing can process pre-mRNA in multiple ways to produce different mature mRNAs. Evolution of the OPRM1 alternative splicing in the mammalian species highlights the special place of the OPRM1 gene in the opioid receptor gene family. Extensive alternative splicing of the OPRM1 gene creates not only RNA and protein diversity but also functional complexity demonstrated by various C-terminal full-length variants and truncated 6-TM variants. © 2014 John Wiley & Sons, Inc.
Keywords: oprm1 gene; alternative pre-mrna splicing; mu opioids; μ-opioid receptor (mor)
Book Title: Pain Genetics: Basic to Translational Science
ISBN: 978-1-118-39884-5
Publisher: John Wiley & Sons, Inc  
Publication Place: Ames, IA
Date Published: 2014-01-01
Start Page: 79
End Page: 98
Language: English
DOI: 10.1002/9781118398890.ch6
PROVIDER: scopus
DOI/URL:
Notes: Book Chapter: 6 -- Export Date: 2 May 2017 -- Source: Scopus
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  1. Yingxian Pan
    126 Pan