CT findings of chemotherapy-induced toxicity: What radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity Journal Article

  

Authors:	Torrisi, J. M.; Schwartz, L. H.; Gollub, M. J.; Ginsberg, M. S.; Bosl, G. J.; Hricak, H.
Article Title:	CT findings of chemotherapy-induced toxicity: What radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity
Abstract:	Cancer chemotherapy has evolved from cytotoxic agents and now includes several new agents that target specific molecules responsible for the regulation of cell growth, nutrient supply, and differentiation. These molecularly targeted therapies have a different mechanism of action than do classic cytotoxic agents, which predominantly attack rapidly proliferating cells. Not surprisingly, therefore, the toxicity of targeted and cytotoxic agents may differ in both clinical and radiologic presentation. Many of the toxicities of targeted therapies are not cumulative or dose dependent, some are asymptomatic, and others may first manifest radiologically. It is imperative that radiologists be aware of these toxicities and that they learn to recognize the relevant findings so that they can provide a complete differential diagnosis and thus play an important role in patient care. (C) RSNA, 2011
Keywords:	chemotherapy; gastrointestinal stromal tumor; syndrome; arterial infusion; metastatic; colorectal-cancer; renal-cell carcinoma; growth-factor receptor; cisplatin-based chemotherapy; posterior leukoencephalopathy syndrome; interstitial lung-disease; hepatic venoocclusive disease; capillary-leak
Journal Title:	Radiology
Volume:	258
Issue:	1
ISSN:	0033-8419
Publisher:	Radiological Society of North America, Inc.
Date Published:	2011-01-01
Start Page:	41
End Page:	56
Language:	English
DOI:	10.1148/radiol.10092129
ACCESSION:	WOS:000285574200007
PROVIDER:	wos
PUBMED:	21183492
Notes:	--- - Review - "Source: Wos"

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