Mechanical communication at the immunological synapse Journal Article

   


Authors: Basu, R.; Huse, M.
Article Title: Mechanical communication at the immunological synapse
Abstract: T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force. In recent years, it has become increasingly clear that synaptic forces influence information transfer both into and out of the lymphocyte. Here, we review our current understanding of synapse mechanics, focusing on its role as an avenue for intercellular communication. © 2016 Elsevier Ltd
Keywords: signal transduction; immunology; t cell; b cell; mechanobiology
Journal Title: Trends in Cell Biology
Volume: 27
Issue: 4
ISSN: 0962-8924
Publisher: Elsevier Inc.  
Date Published: 2017-04-01
Start Page: 241
End Page: 254
Language: English
DOI: 10.1016/j.tcb.2016.10.005
PROVIDER: scopus
PMCID: PMC5367987
PUBMED: 27986534
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008156800&doi=10.1016%2fj.tcb.2016.10.005&partnerID=40&md5=961bfd8dfa0a9d21ea8eea44c610512a
Notes: Review -- Export Date: 4 April 2017 -- Source: Scopus
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MSK Authors
  1. Morgan Huse
    68 Huse
  2. Roshni Basu
    4 Basu
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