Acute myeloid leukemia therapy elicits durable complete response in chemoradio-resistant metastatic paraganglioma Journal Article


Authors: Sait, S.; Kobos, R.; LaQuaglia, M. P.; Pandit-Taskar, N.; Modak, S.
Article Title: Acute myeloid leukemia therapy elicits durable complete response in chemoradio-resistant metastatic paraganglioma
Abstract: Few effective therapeutic options exist for patients with metastatic paraganglioma (PGL). We report the case of a 16-year-old male who developed acute myeloid leukemia (AML) 30 months following the treatment for metastatic PGL. PGL had been refractory to 131I-meta-iodobenzylguanidine and temozolomide therapy. However, there was a major reduction in primary tumor allowing its gross total resection, and complete resolution of metastatic disease following AML-directed therapy that included daunorubicin, cytarabine, and etoposide. He remains in remission for both AML and PGL, 48 months post AML chemotherapy. Alternative chemotherapeutic agents should be considered for metastatic PGL resistant to conventional therapy. © 2016 Wiley Periodicals, Inc.
Keywords: chemotherapy; acute myeloid leukemia; metastatic paraganglioma
Journal Title: Pediatric Blood and Cancer
Volume: 64
Issue: 5
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2017-05-01
Start Page: e26314
Language: English
DOI: 10.1002/pbc.26314
PROVIDER: scopus
PUBMED: 27804217
PMCID: PMC5535780
DOI/URL:
Notes: Article -- Export Date: 4 April 2017 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Shakeel Modak
    250 Modak
  2. Rachel Kobos
    75 Kobos