CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy Journal Article

   


Authors: Chen, N.; Morello, A.; Tano, Z.; Adusumilli, P. S.
Article Title: CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy
Abstract: PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors. © 2017 Taylor & Francis Group, LLC.
Keywords: breast cancer; lung cancer; mesothelioma; immunosuppression; tumor microenvironment; adoptive t-cell therapy; pd-1 blockade
Journal Title: OncoImmunology
Volume: 6
Issue: 2
ISSN: 2162-4011
Publisher: Landes Bioscience  
Date Published: 2017-01-01
Start Page: e1273302
Language: English
DOI: 10.1080/2162402x.2016.1273302
PROVIDER: scopus
PMCID: PMC5353939
PUBMED: 28344886
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011825145&doi=10.1080%2f2162402X.2016.1273302&partnerID=40&md5=27b8091f5ae4238da1a2633fbbe71825
Notes: Article -- Export Date: 4 April 2017 -- Source: Scopus
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MSK Authors
  1. Prasad S Adusumilli
    496 Adusumilli
  2. Aurore Ornella Lauriane Morello
    14 Morello
  3. Nan Chen
    4 Chen
  4. Zachary Tano
    11 Tano
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