Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation Journal Article


Authors: Shah, G. L.; Landau, H.; Londono, D.; Devlin, S. M.; Kosuri, S.; Lesokhin, A. M.; Lendvai, N.; Hassoun, H.; Chung, D. J.; Koehne, G.; Jhanwar, S. C.; Landgren, O.; Levine, R.; Giralt, S. A.
Article Title: Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation
Abstract: We aimed to identify whether the use of autologous hematopoietic cell transplantation (HCT) impacts outcomes for multiple myeloma patients with gains of chromosome 1q (+1q). We retrospectively identified 95 patients, 21% having +1q. For patients with +1q, the overall response rate to induction was 85%, with 40% having ≥ VGPR and 20% achieving a CR, similar to non +1q patients (p =.64). The median PFS from diagnosis with +1q was 2.1 years (95% CI: 1.2–not reached (NR)) vs 4.3 years (95% CI: 3.3 yrs–NR) without +1q (p =.003). Median OS from diagnosis was 4.4 years (95% CI: 2.9–NR) vs not reached, respectively (p =.005). On molecular analysis using the Foundation One Heme assay, the most common mutations seen in +1q patients included TP53 (38%) and KRAS (25%). Overall, gain of 1q portends worse PFS and OS which was not negated by auto HCT. Such patients will likely require additional therapy to improve their survival. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: myeloma; neoplasia; clinical results; marrow and stem cell transplantation; neoplasia–cytogenetics; neoplasia–molecular genetics
Journal Title: Leukemia and Lymphoma
Volume: 58
Issue: 8
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2017-01-01
Start Page: 1823
End Page: 1831
Language: English
DOI: 10.1080/10428194.2016.1260126
PROVIDER: scopus
PUBMED: 28078910
PMCID: PMC5554510
DOI/URL:
Notes: Article -- Export Date: 4 April 2017 -- Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    616 Giralt
  2. Hani Hassoun
    169 Hassoun
  3. Ross Levine
    541 Levine
  4. Guenther Koehne
    180 Koehne
  5. Heather Jolie Landau
    220 Landau
  6. Nikoletta Lendvai
    97 Lendvai
  7. Suresh C Jhanwar
    259 Jhanwar
  8. Alexander Meyer Lesokhin
    135 Lesokhin
  9. David Chung
    99 Chung
  10. Sean McCarthy Devlin
    353 Devlin
  11. Carl Ola Landgren
    252 Landgren
  12. Gunjan Lalitchandra Shah
    116 Shah
  13. Satyajit   Kosuri
    23 Kosuri