Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation Journal Article
| Authors: | Shah, G. L.; Landau, H.; Londono, D.; Devlin, S. M.; Kosuri, S.; Lesokhin, A. M.; Lendvai, N.; Hassoun, H.; Chung, D. J.; Koehne, G.; Jhanwar, S. C.; Landgren, O.; Levine, R.; Giralt, S. A. |
| Article Title: | Gain of chromosome 1q portends worse prognosis in multiple myeloma despite novel agent-based induction regimens and autologous transplantation |
| Abstract: | We aimed to identify whether the use of autologous hematopoietic cell transplantation (HCT) impacts outcomes for multiple myeloma patients with gains of chromosome 1q (+1q). We retrospectively identified 95 patients, 21% having +1q. For patients with +1q, the overall response rate to induction was 85%, with 40% having ≥ VGPR and 20% achieving a CR, similar to non +1q patients (p =.64). The median PFS from diagnosis with +1q was 2.1 years (95% CI: 1.2–not reached (NR)) vs 4.3 years (95% CI: 3.3 yrs–NR) without +1q (p =.003). Median OS from diagnosis was 4.4 years (95% CI: 2.9–NR) vs not reached, respectively (p =.005). On molecular analysis using the Foundation One Heme assay, the most common mutations seen in +1q patients included TP53 (38%) and KRAS (25%). Overall, gain of 1q portends worse PFS and OS which was not negated by auto HCT. Such patients will likely require additional therapy to improve their survival. © 2016 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | myeloma; neoplasia; clinical results; marrow and stem cell transplantation; neoplasia–cytogenetics; neoplasia–molecular genetics |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 58 |
| Issue: | 8 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2017-01-01 |
| Start Page: | 1823 |
| End Page: | 1831 |
| Language: | English |
| DOI: | 10.1080/10428194.2016.1260126 |
| PROVIDER: | scopus |
| PUBMED: | 28078910 |
| PMCID: | PMC5554510 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 April 2017 -- Source: Scopus |
