Integrated molecular characterization of uterine carcinosarcoma Journal Article


Authors: Cherniack, A. D.; Shen, H.; Walter, V.; Stewart, C.; Murray, B. A.; Bowlby, R.; Hu, X.; Ling, S.; Soslow, R. A.; Broaddus, R. R.; Zuna, R. E.; Robertson, G.; Laird, P. W.; Kucherlapati, R.; Mills, G. B.; The Cancer Genome Atlas Research Network; Weinstein, J. N.; Zhang, J.; Akbani, R.; Levine, D. A.
Article Title: Integrated molecular characterization of uterine carcinosarcoma
Abstract: We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest among all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were identified. © 2017 Elsevier Inc.
Keywords: endometrial cancer; gynecologic oncology; gynecologic cancer; emt; uterine carcinosarcoma; the cancer genome atlas; epithelial-to-mesenchymal transition; tgga; translational science; ucs
Journal Title: Cancer Cell
Volume: 31
Issue: 3
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2017-03-13
Start Page: 411
End Page: 423
Language: English
DOI: 10.1016/j.ccell.2017.02.010
PROVIDER: scopus
PUBMED: 28292439
PMCID: PMC5599133
DOI/URL:
Notes: Article -- Export Date: 3 April 2017 -- Source: Scopus
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  1. Robert Soslow
    718 Soslow