Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates Journal Article

   

Authors:	Lewis, B. B.; Carter, R. A.; Pamer, E. G.
Article Title:	Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates
Abstract:	Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice. Copyright © 2016 Elsevier Ltd. All rights reserved.
Keywords:	animal; animals; mice, inbred c57bl; c57bl mouse; growth, development and aging; pathogenicity; microbiology; clostridium difficile; microbial viability; virulence; enterocolitis, pseudomembranous; drug effects; humans; human; bacterial spore; peptoclostridium difficile; secondary bile acid; lithocholic acid; pseudomembranous colitis; spores, bacterial
Journal Title:	Anaerobe
Volume:	41
ISSN:	1075-9964
Publisher:	Elsevier Science, Inc.
Date Published:	2016-10-01
Start Page:	32
End Page:	36
Language:	English
DOI:	10.1016/j.anaerobe.2016.05.010
PUBMED:	27241781
PROVIDER:	scopus
PMCID:	PMC5050091
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013729916&doi=10.1016%2fj.anaerobe.2016.05.010&partnerID=40&md5=a10ce2294d7562763effd2ed7d692c7b
Notes:	Article -- Export Date: 3 April 2017 -- Source: Scopus

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