Clinical use of irinotecan: Current status and future considerations Journal Article
| Author: | Saltz, L. B. |
| Article Title: | Clinical use of irinotecan: Current status and future considerations |
| Abstract: | Irinotecan (CPT-11, Camptosar), a semisynthetic, water-soluble derivative of the plant alkaloid camptothecin, is a drug which has undergone extensive clinical investigation worldwide. It is, at this time, commercially available in the United States for the treatment of fluorouracil-refractory colorectal cancer. In this review, I will discuss the current approved clinical use, discuss the issues of toxicity and its management, and consider some of the ongoing clinical investigations which are exploring possible future uses for this agent. |
| Keywords: | clinical trial; neutropenia; cisplatin; fluorouracil; area under the curve; diarrhea; drug potentiation; colorectal cancer; bone marrow suppression; nausea; vomiting; 7 ethyl 10 hydroxycamptothecin; dexamethasone; irinotecan; folinic acid; granisetron; ondansetron; loperamide; drug metabolite; alopecia; granulocytopenia; atropine; intravenous drug administration; oral drug administration; cpt-11; human; priority journal; article; topoisomerase i inhibitor |
| Journal Title: | The Oncologist |
| Volume: | 2 |
| Issue: | 6 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 1997-01-01 |
| Start Page: | 402 |
| End Page: | 409 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 10388075 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
