Spinal analgesic activity of orphanin FQ/nociceptin and its fragments Journal Article
| Authors: | King, M. A.; Rossi, G. C.; Chang, A. H.; Williams, L.; Pasternak, G. W. |
| Article Title: | Spinal analgesic activity of orphanin FQ/nociceptin and its fragments |
| Abstract: | Previous work reveals that orphanin FQ/nociceptin (OFQ/N) administered supraspinally produces an initial hyperalgesic response followed by analgesia. Spinally, OFQ/N elicits a rapidly appearing, naltrexone-reversible, dose-dependent analgesia in the tailflick assay without any indication of hyperalgesia. Two OFQ/N fragments, OFQ/N (1-7) and OFQ/N (1-11), are active, but far weaker. Blockade of sigma receptors with haloperidol enhances the analgesic potency of spinal OFQ/N, OFQ/N (1-7) and OFQ/N (1-11), but not as dramatically as supraspinal OFQ. Antisense probes targeting the second and third coding exons, but not the first exon, of the cloned mouse OFQ/N receptor (KOR-3) partially block OFQ/N analgesia. |
| Keywords: | controlled study; exons; nonhuman; mouse; animals; mice; haloperidol; animal experiment; drug synergism; mice, inbred strains; cloning, molecular; spinal cord; peptide fragments; analgesics; analgesia; hyperalgesia; nociception; tail flick test; opiate receptor; opioid peptides; receptors, sigma; nociceptin; antisense oligodeoxynucleotide; opiate agonist; receptors, opioid; male; priority journal; article; antisense elements (genetics); sigma opiate receptor; orphanin fq; kor-3; orl-1 |
| Journal Title: | Neuroscience Letters |
| Volume: | 223 |
| Issue: | 2 |
| ISSN: | 0304-3940 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1997-02-21 |
| Start Page: | 113 |
| End Page: | 116 |
| Language: | English |
| DOI: | 10.1016/s0304-3940(97)13414-0 |
| PUBMED: | 9089686 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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