Familial Hodgkin's and non-Hodgkin's lymphoma: Different patterns in first-degree relatives Journal Article
| Authors: | Siebert, R.; Louie, D.; Lacher, M.; Schluger, A.; Offit, K. |
| Article Title: | Familial Hodgkin's and non-Hodgkin's lymphoma: Different patterns in first-degree relatives |
| Abstract: | In order to evaluate the importance of genetic susceptibility in Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) we retrospectively analysed 31 families with lymphoma in first-degree relatives containing a total of 65 affected persons. We observed 20 HD/HD, 8 NHL/HD and 8 NHL/NHL pairs with median ages of diagnosis of 27, 36 and 48 years, respectively (p < 0.001). In HD/HD sib pairs were predominant in contrast to parent/child pairs in NHL/NHL (p = 0.04). There was a higher frequency of disease with impaired immune function in NHL/NHL than in other pairs (p = 0.01). Comparison of ages and times of incidence of the pairs as well as sex-concordance rates are consistent with an age-specific genetic susceptibility to HD, but suggest a time-specific exposure in some NHL-prone families with or without compromised immune function. |
| Keywords: | adolescent; adult; child; preschool child; school child; aged; aged, 80 and over; child, preschool; middle aged; retrospective studies; major clinical study; genetics; age factors; retrospective study; hodgkin disease; time factors; nonhodgkin lymphoma; non-hodgkin's lymphoma; lymphoma, non-hodgkin; genetic susceptibility; chi-square distribution; familial cancer; relative; familial; family; disease susceptibility; hodgkin's disease; first-degree relatives; humans; human; male; female; priority journal; article |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 27 |
| Issue: | 5-6 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 1997-01-01 |
| Start Page: | 503 |
| End Page: | 507 |
| Language: | English |
| PUBMED: | 9477132 |
| PROVIDER: | scopus |
| DOI: | 10.3109/10428199709058317 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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