Increased methotrexate polyglutamylation in acute megakaryocytic leukemia (M7) compared to other subtypes of acute myelocytic leukemia Journal Article

  

Authors:	Argiris, A.; Longo, G. S. A.; Gorlick, R.; Tong, W.; Steinherz, P.; Bertino, J. R.
Article Title:	Increased methotrexate polyglutamylation in acute megakaryocytic leukemia (M7) compared to other subtypes of acute myelocytic leukemia
Abstract:	Acute myelocytic leukemia (AML) is a malignancy that is intrinsically resistant to methotrexate (MTX). AML blasts, when incubated with radiolabeled MTX, form lower amounts of long chain polyglutamates compared to acute lymphocytic leukemia (ALL) blasts, thus providing an explanation for their lack of responsiveness to MTX. Leukemic blasts obtained from two children with acute megakaryocytic leukemia (M7 subtype) when incubated with radiolabeled MTX showed increased accumulation of total as well as long chain MTX polyglutamates, comparable to levels previously demonstrated in another subtype of AML, acute monocytic leukemia (M5), as well as in blasts from patients with pre-B ALL. We suggest that M7-AML patients with blasts showing increased MIX polyglutamylation might benefit from treatment with MTX.
Keywords:	adolescent; adult; acute granulocytic leukemia; major clinical study; methotrexate; bone marrow; antineoplastic combined chemotherapy protocols; drug resistance, neoplasm; infant; hematopoietic stem cells; acute lymphocytic leukemia; folic acid antagonist; injections, spinal; polyglutamic acid; acute megakaryocytic leukemia; leukemia, megakaryocytic, acute; leukemia, myelocytic, acute; humans; human; male; female; priority journal; article; acute myelocytic leukemia; polyglutamylation
Journal Title:	Leukemia
Volume:	11
Issue:	6
ISSN:	0887-6924
Publisher:	Nature Publishing Group
Date Published:	1997-06-01
Start Page:	886
End Page:	889
Language:	English
PUBMED:	9177445
PROVIDER:	scopus
DOI:	10.1038/sj.leu.2400647
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030927589&partnerID=40&md5=de6e4ed942d057093c083c4d2bd152e3
Notes:	Article -- Export Date: 17 March 2017 -- Source: Scopus

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