Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality Journal Article


Authors: Bullard, D. C.; King, P. D.; Hicks, M. J.; Dupont, B.; Beaudet, A. L.; Elkon, K. B.
Article Title: Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality
Abstract: MRL/MpJ-Faslpr (Faslpr) mice develop a rapidly fatal form of systemic autoimmune disease characterized by glomerulonephritis and vasculitis similar to severe cases of systemic lupus erythematosus in humans. To evaluate the requirement for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of tissue injury in this model, we created ICAM-1-deficient MRL/MpJ-Faslpr (ICAM-1/Faslpr) mice. ICAM-1 deficiency resulted in a striking improvement in the survival of Faslpr mice (median ± SEM survival of Faslpr = 26 ± 1.7 vs ICAM-1/Faslpr = 47 ± 2.4 wk, p < 0.0001) and the increased survival was associated with delayed elevations of blood urea nitrogen levels in the ICAM-1/Faslpr mice. Histologic examination of the ICAM-1/Faslpr mice revealed an overall reduction in glomerular disease and a significant reduction in vasculitis in the kidney, lung, skin, and salivary glands when compared with Faslpr. These findings indicate that ICAM-1 plays a major role in development of glomerular and vascular injury in Faslpr mice.
Keywords: mortality; mouse; animal; animals; mice; physiology; blood; immunoglobulin g; glomerulonephritis; antinuclear antibody; autoimmune diseases; autoimmune disease; ultrastructure; intercellular adhesion molecule 1; intercellular adhesion molecule-1; mice, inbred mrl lpr; vasculitis; kidney glomerulus; glomerulus; article; antibodies, antinuclear; murphy roths large lymphoproliferative mouse
Journal Title: Journal of Immunology
Volume: 159
Issue: 4
ISSN: 0022-1767
Publisher: The American Association of Immunologists, Inc  
Date Published: 1997-08-15
Start Page: 2058
End Page: 2067
Language: English
PUBMED: 9257874
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
Citation Impact
MSK Authors
  1. Bo Dupont
    264 Dupont
  2. Philip D. King
    19 King