Atlas generation for intraoperative high dose rate brachytherapy Journal Article

  


Authors: Anderson, L. L.; Hoffman, M. R.; Harrington, P. J.; Starkschall, G.
Article Title: Atlas generation for intraoperative high dose rate brachytherapy
Abstract: A computer atlas of treatment plans has been prepared for intraoperative brachytherapy of tumor beds by high dose rate (HDR) remote afterloading, using a flexible mold applicator. The applicator consists of a rectangular silicone rubber pad with as many as 24 parallel catheters embedded at 0.5 cm from its treatment surface and spaced 1 cm apart. In the atlas, dwell positions are at 1-cm intervals along each catheter, and the intended target surface is 0.5 cm from the applicator surface. Dwell-time optimization makes use of existing least-squares algorithms to bring the dose at treatment depth as close as possible to the prescription dose, consistent with comparable dose uniformity at the applicator surface. More than 5000 dwell time plans were generated for each rectangular source array with dimensions in the range 3 x 3 to 24 x 40. Each array size was optimized at two dose levels (10 Gy and 15 Gy) and for each of three curvatures (none and, with a 10-cm radius, transverse and longitudinal). For mold treatments of tumor beds intraoperatively by HDR remote afterloading, use of a planning atlas not only avoids the need for radiographic imaging (precluded by surgical retractors) but also reduces planning time and the likelihood of error.
Keywords: treatment planning; cancer radiotherapy; radiation dose; quality control; dosimetry; intraoperative period; brachytherapy; intraoperative; atlas; high dose rate; priority journal; article
Journal Title: Journal of Brachytherapy International
Volume: 13
Issue: 4
ISSN: 1094-4540
Publisher: Endocurietherapy Research Foundation  
Date Published: 1997-10-01
Start Page: 333
End Page: 340
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031413620&partnerID=40&md5=4db148401142ec9be53a9801e516a448
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus