The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma Journal Article

  


Authors: Chi, D. S.; Mychalczak, B.; Saigo, P. E.; Rescigno, J.; Brown, C. L.
Article Title: The role of whole-pelvic irradiation in the treatment of early-stage uterine carcinosarcoma
Abstract: Thirty-eight patients with Stage I and II uterine carcinosarcoma were treated by surgery with and without whole-pelvic irradiation (WPI) at our institution from 1975 to 1993. Ten patients (8 Stage I and 2 Stage II) were treated with surgery alone, while 28 patients (20 Stage I and 8 Stage II) received WPI in addition to surgery. With a median follow-up of 75 months (range 25-220 months), a trend toward a decreased rate of pelvic recurrence in those receiving WPI (6/28, 21%) compared to those treated with surgery alone (5/10, 50%) was observed (P = 0.09). There was no difference in the rate of distant recurrence between those receiving WPI (12/28, 43%) and those who did not (4/10, 40%) (P = 0.9). There was also no difference in the 2- and 5-year Kaplan-Meier survival estimates for the patients receiving WPI (79 and 59%, respectively) compared to those who did not receive WPI (60 and 60%, respectively) (P = 0.84). In this small series, the addition of whole-pelvic irradiation to primary surgery did not improve survival; however, a trend toward improved pelvic control was observed, suggesting a possible benefit for pelvic irradiation that should be studied in future trials.
Keywords: cancer survival; clinical article; treatment outcome; aged; aged, 80 and over; middle aged; cancer surgery; retrospective studies; cancer radiotherapy; radiotherapy, adjuvant; cancer staging; follow-up studies; neoplasm staging; neoplasm recurrence, local; uterine neoplasms; uterus carcinoma; carcinosarcoma; abdominal radiotherapy; hemibody irradiation; humans; human; female; priority journal; article
Journal Title: Gynecologic Oncology
Volume: 65
Issue: 3
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 1997-06-01
Start Page: 493
End Page: 498
Language: English
DOI: 10.1006/gyno.1997.4676
PUBMED: 9190981
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031172699&doi=10.1006%2fgyno.1997.4676&partnerID=40&md5=6459f86fb429e0a7418f5038b28e133c
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
MSK Authors
  1. John Rescigno
    8 Rescigno
  2. Borys Mychalczak
    97 Mychalczak
  3. Carol Brown
    161 Brown
  4. Dennis S Chi
    658 Chi
  5. Patricia E Saigo
    91 Saigo
Related MSK Work