Chemotherapy and total parenteral nutrition for advanced ovarian cancer with bowel obstruction Journal Article

  


Authors: Abu-Rustum, N. R.; Barakat, R. R.; Venkatraman, E.; Spriggs, D.
Article Title: Chemotherapy and total parenteral nutrition for advanced ovarian cancer with bowel obstruction
Abstract: We retrospectively reviewed the medical records of 21 patients with advanced epithelial ovarian carcinoma treated with intravenous chemotherapy in an attempt to restore intestinal function following small-bowel obstruction. All patients had a drainage gastrostomy tube placed for palliation of vomiting, and 11 patients received concomitant total parenteral nutrition (TPN). Eight (38%) patients were treated with single-agent paclitaxel, 7 (33%) received platinum-based regimens, and 6 (29%) received other second-line chemotherapy. The median survival for all patients post- gastrostomy tube placement was 84 days. The median survival for patients with recurrent ovarian cancer who received salvage chemotherapy and TPN was 89 days, longer than for patients who received salvage chemotherapy alone (71 days) (P = 0.031). Two of three patients with newly diagnosed ovarian cancer and concomitant bowel obstruction had sufficient temporary response from chemotherapy with resolution of obstruction and removal of the gastrostomy tube. Chemotherapy was ineffective in restoring bowel function in heavily pretreated patients with recurrent disease.
Keywords: adult; cancer chemotherapy; cancer survival; clinical article; aged; salvage therapy; advanced cancer; paclitaxel; ovary cancer; total parenteral nutrition; intestine obstruction; dietary intake; intestine function; human; female; priority journal; article
Journal Title: Gynecologic Oncology
Volume: 64
Issue: 3
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 1997-03-01
Start Page: 493
End Page: 495
Language: English
DOI: 10.1006/gyno.1996.4605
PUBMED: 9062158
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031104865&doi=10.1006%2fgyno.1996.4605&partnerID=40&md5=0fe135e803a4b8430d94ac9b12479bf3
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Venkatraman Ennapadam Seshan
    382 Seshan
  2. Richard R Barakat
    629 Barakat
  3. Nadeem Abu-Rustum
    888 Abu-Rustum
  4. David R Spriggs
    325 Spriggs
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