Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Journal Article

Authors: Zou, H.; Wieser, R.; Massagué, J.; Niswander, L.
Article Title: Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage
Abstract: The bone morphogenetic proteins (BMPs), TGFβ superfamily members, play diverse roles in embryogenesis, but how the BMPs exert their action is unclear and how different BMP receptors (BMPRs) contribute to this process is not known. Here we demonstrate that the two type I BMPRs, BMPR-IA and BMPR- IB, regulate distinct processes during chick limb development. BmpR-IB expression in the embryonic limb prefigures the future cartilage primordium, and its activity is necessary for the initial steps of chondrogenesis. During later chondrogenesis, BmpR-IA is specifically expressed in prehypertrophic chondrocytes. BMPR-IA regulates chondrocyte differentiation, serving as a downstream mediator of Indian Hedgehog (IHH) function in both a local signaling loop and a longer-range relay system to PTHrP. BMPR-IB also regulates apoptosis: Expression of activated BMPR-IB results in increased cell death, and we showed previously that dominant-negative BMPR-IB inhibits apoptosis. Our studies indicate that in TGFβ signaling systems, different type I receptor isoforms are dedicated to specific functions during embryogenesis.
Keywords: signal transduction; protein expression; gene mutation; mutation; nonhuman; proteins; animals; cell death; apoptosis; gene expression; bone morphogenetic protein; transforming growth factor beta; embryo; hedgehog proteins; embryo development; cell differentiation; rna; in situ hybridization; gene expression regulation, developmental; protein-serine-threonine kinases; extremities; trans-activators; erinaceidae; chick embryo; bone morphogenetic proteins; receptors, growth factor; limb development; cartilage cell; cartilage; bone morphogenetic protein receptors, type i; chondrogenesis; parathyroid hormone-related protein; priority journal; article; cartilage differentiation; bmp receptor
Journal Title: Genes and Development
Volume: 11
Issue: 17
ISSN: 0890-9369
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 1997-09-01
Start Page: 2191
End Page: 2203
Language: English
PUBMED: 9303535
PROVIDER: scopus
PMCID: PMC275391
DOI: 10.1101/gad.11.17.2191
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Joan Massague
    287 Massague
  2. Hongyan   Zou
    7 Zou