Thyroid dysfunction as a late effect in survivors of pediatric medulloblastoma/primitive neuroectodermal tumors: A comparison of hyperfractionated versus conventional radiotherapy Journal Article
| Authors: | Chin, D.; Sklar, C.; Donahue, B.; Uli, N.; Geneiser, N.; Allen, J.; Nirenberg, A.; David, R.; Kohn, B.; Oberfield, S. E. |
| Article Title: | Thyroid dysfunction as a late effect in survivors of pediatric medulloblastoma/primitive neuroectodermal tumors: A comparison of hyperfractionated versus conventional radiotherapy |
| Abstract: | BACKGROUND. Primary hypothyroidism is a common sequela of craniospinal radiotherapy in the treatment of pediatric brain tumors. METHODS. The authors compared the incidence of primary hypothyroidism after hyperfractionated radiotherapy (HFRT) (n = 14 patients) versus conventionally fractionated radiotherapy (CRT) (n = 34 patients) in a group of pediatric patients with medulloblastoma/primitive neuroectodermal tumors (MB/PNET). RESULTS. The mean age at the time of tumor diagnosis was 7.9 years in the HFRT group and 8.4 years in the CRT group. The patients were followed for a mean of 4.6 years (HFRT) and 8.3 years (CRT) after diagnosis. Mean radiation doses to the thyroid were similar in both radiotherapy groups (29 gray [Gy] [HFRT] vs. 24 Gy [CRT]). Approximately 14% of the HFRT and 62% of the CRT patients developed primary hypothyroidism within a similar period after irradiation (3.2 years [HFRT] vs. 3.0 years [CRT]). Analysis by cumulative incidence function demonstrated a significant difference in the risk of developing thyroid dysfunction between these two groups of patients (P = 0.02). CONCLUSIONS. The current study findings suggest that the use of HFRT in the treatment of pediatric patients with MB/PNET is associated with a lower risk of these patients developing primary hypothyroidism. |
| Keywords: | adolescent; child; clinical article; controlled study; child, preschool; brain neoplasms; follow-up studies; radiotherapy dosage; radiotherapy; radiation injury; time factors; risk assessment; radiation dose fractionation; medulloblastoma; radiation injuries; hypothyroidism; neuroectoderm tumor; hyperfractionated radiotherapy; neuroectodermal tumors, primitive; primitive neuroectodermal tumor; thyroid disease; humans; human; male; female; priority journal; article; late effect of radiation; thyroid dysfunction |
| Journal Title: | Cancer |
| Volume: | 80 |
| Issue: | 4 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1997-08-15 |
| Start Page: | 798 |
| End Page: | 804 |
| Language: | English |
| DOI: | 10.1002/(sici)1097-0142(19970815)80:4<798::aid-cncr19>3.0.co;2-o |
| PUBMED: | 9264364 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
