Molecular and functional analysis of cadherin-based adherens junctions Journal Article
| Authors: | Yap, A. S.; Brieher, W. M.; Gumbiner, B. M. |
| Article Title: | Molecular and functional analysis of cadherin-based adherens junctions |
| Abstract: | Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. The extracellular domains of cadherins form parallel dimers that possess intrinsic homophilic-binding activity. Cytoplasmic interactions can influence the function of the ectodomain by a number of potential mechanisms, including redistribution of binding sites into clusters, providing cytosketetal anchorage, and mediating physiological regulation of cadherin function. Adherens junctions are likely to serve specific, specialized functions beyond the basic adhesive process. These functions include coupling cytoskeletal force generation to strongly adherent sites on the cell surface and the regulation of intracellular signaling events. |
| Keywords: | signal transduction; gene cluster; nonhuman; binding affinity; protein localization; protein analysis; animals; actin; signaling; drosophila; morphogenesis; diagnostic approach route; binding site; binding sites; molecular interaction; cell junction; tacrolimus; cadherin; cell adhesion; cadherins; cytoskeleton; catenin; priority journal; article; catenins |
| Journal Title: | Annual Review of Cell and Developmental Biology |
| Volume: | 13 |
| ISSN: | 1081-0706 |
| Publisher: | Annual Reviews |
| Date Published: | 1997-11-01 |
| Start Page: | 119 |
| End Page: | 146 |
| Language: | English |
| DOI: | 10.1146/annurev.cellbio.13.1.119 |
| PUBMED: | 9442870 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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