Molecular and functional analysis of cadherin-based adherens junctions Journal Article


Authors: Yap, A. S.; Brieher, W. M.; Gumbiner, B. M.
Article Title: Molecular and functional analysis of cadherin-based adherens junctions
Abstract: Adherens junctions are specialized forms of cadherin-based adhesive contacts important for tissue organization in developing and adult organisms. Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. The extracellular domains of cadherins form parallel dimers that possess intrinsic homophilic-binding activity. Cytoplasmic interactions can influence the function of the ectodomain by a number of potential mechanisms, including redistribution of binding sites into clusters, providing cytosketetal anchorage, and mediating physiological regulation of cadherin function. Adherens junctions are likely to serve specific, specialized functions beyond the basic adhesive process. These functions include coupling cytoskeletal force generation to strongly adherent sites on the cell surface and the regulation of intracellular signaling events.
Keywords: signal transduction; gene cluster; nonhuman; binding affinity; protein localization; protein analysis; animals; actin; signaling; drosophila; morphogenesis; diagnostic approach route; binding site; binding sites; molecular interaction; cell junction; tacrolimus; cadherin; cell adhesion; cadherins; cytoskeleton; catenin; priority journal; article; catenins
Journal Title: Annual Review of Cell and Developmental Biology
Volume: 13
ISSN: 1081-0706
Publisher: Annual Reviews  
Date Published: 1997-11-01
Start Page: 119
End Page: 146
Language: English
DOI: 10.1146/annurev.cellbio.13.1.119
PUBMED: 9442870
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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  1. William M Brieher
    14 Brieher