Epithelioid sarcoma: Clinical behavior and prognostic factors of survival Journal Article
| Authors: | Ross, H. M.; Lewis, J. J.; Woodruff, J. M.; Brennan, M. F. |
| Article Title: | Epithelioid sarcoma: Clinical behavior and prognostic factors of survival |
| Abstract: | Background: Epithelioid sarcoma is a rare histologic subtype of sarcoma. The clinical behavior and prognostic factors influencing survival in this disease are examined. Methods: A review of clinicopathologic features of patients with epithelioid sarcoma prospectively followed between July 1982 and July 1995 at Memorial Sloan-Kettering Cancer Center was performed. Kaplan-Meier and log-rank analysis were used. Results: Eleven men (69%) and five women (31%) were treated during this period. Mean age at diagnosis was 33 years, and length of symptoms before diagnosis was 18 months. Tumors presented in the trunk in 44% of patients, the lower extremity in 31%, and the upper extremity in 25%. Median follow-up time was 45 months. At least one local recurrence was experienced by 69% of patients. Metastases to regional lymph nodes during the course of the disease developed in 44% of patients and to the lungs in 44%. Median survival was 88.8 months, with a 66% 5-year survival rate. Pulmonary metastasis was correlated with decreased survival. Conclusions: A delay in diagnosis of epithelioid sarcoma is common. Epithelioid sarcoma differs from other sarcoma subtypes in propensity for nodal spread and local recurrence. Careful follow-up evaluating local recurrence, nodal spread, and pulmonary metastases is warranted. Published by Lippincott-Raven Publishers © 1997 The Society of Surgical Oncology, Inc. |
| Keywords: | adolescent; adult; treatment outcome; aged; middle aged; survival rate; review; antineoplastic agents; adjuvant therapy; comparative study; radiotherapy, adjuvant; follow up; follow-up studies; lymph node metastasis; antineoplastic agent; lymphatic metastasis; prospective study; prospective studies; metastasis; neoplasm recurrence, local; pathology; time; time factors; sarcoma; tumor recurrence; epithelioid sarcoma; soft tissue neoplasms; soft tissue tumor; humans; human; male; female; article; sarcoma treatment |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 4 |
| Issue: | 6 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 1997-09-01 |
| Start Page: | 491 |
| End Page: | 495 |
| Language: | English |
| PUBMED: | 9309338 |
| PROVIDER: | scopus |
| DOI: | 10.1007/BF02303673 |
| DOI/URL: | |
| Notes: | Article -- Presented at the 49th Annual Cancer Symposium of The Society of Surgical Oncology that took place 1996 Mar 21-24 in Atlanta, GA -- Export Date: 17 March 2017 -- Source: Scopus |
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