Lymphocyte-rich well-differentiated liposarcoma: Report of nine cases Journal Article

  


Authors: Argani, P.; Facchetti, F.; Inghirami, G.; Rosai, J.
Article Title: Lymphocyte-rich well-differentiated liposarcoma: Report of nine cases
Abstract: Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.
Keywords: adult; clinical article; human tissue; aged; middle aged; histopathology; follow-up studies; polymerase chain reaction; t lymphocyte; t-lymphocytes; peritoneal neoplasms; diagnosis, differential; differential diagnosis; tumor differentiation; hodgkin disease; time factors; immunoenzyme techniques; molecular sequence data; receptors, antigen, t-cell; lymphoma; base sequence; retroperitoneal neoplasms; lymphocytes; mesentery; liposarcoma; granuloma, plasma cell; pseudolymphoma; castleman's disease; giant lymph node hyperplasia; inflammatory; t lymphocyte receptor gene; humans; human; male; female; article
Journal Title: American Journal of Surgical Pathology
Volume: 21
Issue: 8
ISSN: 0147-5185
Publisher: Lippincott Williams & Wilkins  
Date Published: 1997-08-01
Start Page: 884
End Page: 895
Language: English
DOI: 10.1097/00000478-199708000-00002
PUBMED: 9255251
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030771957&doi=10.1097%2f00000478-199708000-00002&partnerID=40&md5=52cb7d4f86a46ff7d0546acc04908e06
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Juan Rosai
    181 Rosai
  2. Pedram Argani
    19 Argani
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