Thymic neuroblastoma in adults: Report of three cases with special emphasis on its association with the syndrome of inappropriate secretion of antidiuretic hormone Journal Article

  

Authors:	Argani, P.; Erlandson, R. A.; Rosai, J.
Article Title:	Thymic neuroblastoma in adults: Report of three cases with special emphasis on its association with the syndrome of inappropriate secretion of antidiuretic hormone
Abstract:	We report three cases of neuroblastoma arising within the thymus of elderly patients. All tumors consisted of primitive neuroblasts showing focal gangliocytic differentiation within nests of neuropil. All stained for neuroendocrine markers but were negative for cytokeratins and for the MIC2 gene product. One tumor was associated with the syndrome of inappropriate secretion of antidiuretic hormone, an endocrinopathy we found in three of five cases reports of thymic neuroblastoma in adults. Immunohistochemical stains confirmed production of antidiuretic hormone by this tumor. One patient died of progressive disease, one patient is disease free at 18 months, and the other patient died of unrelated causes, a spectrum that reflects the variable clinical behavior others have reported. The possible histogenesis of these purely neural tumors includes malignant transformation of a mediastinal teratoma, aberrantly located sympathetic ganglia, neuroectodermal cells native to the normal thymus, and precursors of thymic epithelial cells that have differentiated along neural lines.
Keywords:	immunohistochemistry; controlled study; human tissue; aged; aged, 80 and over; case report; disease marker; microscopy, electron; disease association; gene product; thymus; thymus gland; neuroblastoma; teratoma; cytokeratin; keratins; thymoma; mediastinum tumor; mediastinal neoplasms; nerve cell differentiation; sympathetic ganglion; neuropil; neuroectoderm tumor; thymus neoplasms; carcinoid tumor; inappropriate vasopressin secretion; inappropriate adh syndrome; vasopressin; synaptophysin; histogenesis; phosphopyruvate hydratase; chromogranins; humans; human; male; female; priority journal; article; antidiuretic hormone [adh]
Journal Title:	American Journal of Clinical Pathology
Volume:	108
Issue:	5
ISSN:	0002-9173
Publisher:	Oxford University Press
Date Published:	1997-11-01
Start Page:	537
End Page:	543
Language:	English
PUBMED:	9353092
PROVIDER:	scopus
DOI:	10.1093/ajcp/108.5.537
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030696503&partnerID=40&md5=a998711f5e462d99e0d01c0bff8e7b8f
Notes:	Article -- Export Date: 17 March 2017 -- Source: Scopus

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