Renal cyst formation in patients treated with crizotinib for non-small cell lung cancer—Incidence, radiological features and clinical characteristics Journal Article

   

Authors:	Halpenny, D. F.; McEvoy, S.; Li, A.; Hayan, S.; Capanu, M.; Zheng, J.; Riely, G.; Ginsberg, M. S.
Article Title:	Renal cyst formation in patients treated with crizotinib for non-small cell lung cancer—Incidence, radiological features and clinical characteristics
Abstract:	Treatment with the ALK inhibitor crizotinib has been associated with complex renal cyst formation in patients with non-small cell lung cancer (NSCLC). Using patients treated with crizotinib, we aimed to evaluate the incidence of renal cyst formation, to identify risk factors for cyst formation and to provide a radiological description of cyst characteristics. Patients with ALK-positive NSCLC treated with crizotinib were retrospectively identified from an institutional database. Computed tomography (CT) imaging performed prior to and during crizotinib treatment was retrospectively reviewed to assess the size and complexity of pre-existing cysts, new cysts, and enlarging cysts. Demographic data including age, sex, ethnicity, smoking history and length of treatment were also recorded. Data from 60 patients with NSCLC treated with crizotinib at our institution between 6/5/2009 and 7/1/2015 were collected. 57 had CT imaging before and during treatment. Mean length of imaging follow-up was 18 months. 9 (16%) patients had cysts which enlarged or developed de novo during treatment. 2 (4%) patients developed complex renal cysts (1 of these patients also developed complex hepatic cysts). Female gender (p = 0.008) and the presence of renal cysts on baseline scans (p = 0.044) were significantly associated with cyst formation or growth. Renal cyst formation or growth occurred in 16% of crizotinib-treated patients. Women and those with pre-existing cysts were at greatest risk. Although the potential causal relationship between crizotinib use and renal cyst formation has yet to be fully defined, it is important for radiologists and clinicians to be aware of this finding. © 2017
Keywords:	lung cancer; crizotinib; alk rearrangement; renal cystic lesion
Journal Title:	Lung Cancer
Volume:	106
ISSN:	0169-5002
Publisher:	Elsevier Ireland Ltd.
Date Published:	2017-04-01
Start Page:	33
End Page:	36
Language:	English
DOI:	10.1016/j.lungcan.2017.01.010
PROVIDER:	scopus
PUBMED:	28285691
PMCID:	PMC5506846
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011579710&doi=10.1016%2fj.lungcan.2017.01.010&partnerID=40&md5=ae2a8abb9dc46ae01f3715d278d960f5
Notes:	Article -- Export Date: 2 March 2017 -- Source: Scopus

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