Molecular pathways: Deciphering mechanisms of resistance to macrophage-targeted therapies Journal Article
| Authors: | Quail, D. F.; Joyce, J. A. |
| Article Title: | Molecular pathways: Deciphering mechanisms of resistance to macrophage-targeted therapies |
| Abstract: | Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions or reprogramming toward an antitumorigenic phenotype, with varying degrees of efficacy. Here, we review preclinical and clinical strategies to target macrophages in cancer and discuss potential explanations for why some strategies are effective while other approaches have shown limited success. © 2016 AACR. |
| Journal Title: | Clinical Cancer Research |
| Volume: | 23 |
| Issue: | 4 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2017-02-15 |
| Start Page: | 876 |
| End Page: | 884 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-16-0133 |
| PROVIDER: | scopus |
| PUBMED: | 27895033 |
| PMCID: | PMC5453188 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 March 2017 -- Source: Scopus |
