Androgen receptor signaling in salivary gland cancer Journal Article
| Authors: | Dalin, M. G.; Watson, P. A.; Ho, A. L.; Morris, L. G. T. |
| Article Title: | Androgen receptor signaling in salivary gland cancer |
| Abstract: | Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma. Successful treatment with anti-androgen therapy in other androgen receptor-positive malignancies such as prostate and breast cancer has inspired researchers to investigate this treatment in salivary gland cancer as well. In this review, we describe the prevalence, biology, and therapeutic implications of androgen receptor signaling in salivary gland cancer. © 2017 by the authors; licensee MDPI, Basel, Switzerland. |
| Keywords: | androgen receptor; salivary gland cancer; salivary duct carcinoma; androgen-deprivation therapy (adt) |
| Journal Title: | Cancers |
| Volume: | 9 |
| Issue: | 2 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2017-02-01 |
| Start Page: | 17 |
| Language: | English |
| DOI: | 10.3390/cancers9020017 |
| PROVIDER: | scopus |
| PUBMED: | 28208703 |
| PMCID: | PMC5332940 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 March 2017 -- Source: Scopus |
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